Sanofi

Elf Sanofi

Philippe Soubrie

Georges Garcia

Alberto Bianchetti

Umberto Guzzi

Marco Baroni

Gerard R Le Fur

Tiziano Croci

Alain Di Malta

Antonina Giudice

Jacques Simiand

Martine Poncelet

Vincent Santucci

Michele Arnone

Alain D Malta

G Erard Le Fur

Christiane Gueudet

The invention relates to the use of NK.sub.1 receptor antagonists for the preparation of drugs with a cardioregulatory action, intended in particular for controlling heart rate disorders and cardiac dysrhythtmia.

Use of NK.sub.1 receptor antagonists for preparing cardio-regulatory

The present invention concerns the use of 4-amino-1-(2-pyridyl)piperidines of general formula (I') ##STR1## wherein R' represents hydrogen, a halogen atom, a methyl, methylthio, trifluoromethyl, trifluoromethylthio, (C.sub.1 -C.sub.3)alkoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, or phenoxy group optionally substituted with a halogen atom, a trifluoromethyl, (C.sub.1 -C.sub.3)alkyl, (C.sub.1 -C.sub.3)alkoxy, (C.sub.1 -C.sub.3)alkylthio, or cyano group, or of a pharmaceutically acceptable salt thereof, for the preparation of a medicament for the treatment or prophylaxis of those conditions deriving from disorders of the serotoninergic systems wherein a serotoninergic action selectively mediated by the 5-HT.sub.3 receptors is required, e.g. affective disorders, anxiety, psychotic troubles, constipation.

Use of 4-amino-1-(2-pyridyl)piperidines for the preparation of a

A compound of formula ##STR1## and its acid addition salts are useful in the treatment of sexual dysfunctions in male mammals.

Arylpiperidine derivative, process for the preparation thereof and

Compounds of the formula ##STR1## in which: Z represents a halogen or a cyano, acetyl, trifluoroacetyl, nitro, C.sub.1 -C.sub.4 alkylthio, carboxyl, phosphono, dialkoxyphosphonyl or alkoxycarbonyl group, the alkylthio and alkoxy groups containing from 1 to 3 carbon atoms;

Chroman derivative active on the central nervous system, their method of

Novel chroman derivatives active on the central nervous system, their

A method of treatment of depressive states which comprises administering in mammals in need thereof an effective amount of a compound ##STR1## R.sub.1 represents hydrogen, a halogen atom, a cyano group a nitro group, an acetyl group or a trifluoromethyl group;

Chroman derivatives for the treatment of depressive states

A method of treatment of anxiety and depression in mammals is described which comprises administering to a mammal in need thereof an effective amount of a trifluoromethylphenyl-tetrahydropyridine derivative of formula I ##STR1## wherein Alk represents a straight or branched (C.sub.1 -C.sub.4)alkylene chain and R is selected from the group consisting of cyano, acetyl, (C.sub.3 -C.sub.7)cycloalkyl, pyridyl, 1-oxide-pyridyl and naphthyl, or of a pharmaceutically acceptable salt thereof.

Method of treatment of anxiety and anxio-depressive disorders

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Saint Mathieu de Treviers, France

Philippe Soubrie