Institut National De La Sante Et De La Recherche Medicale

Université De Franche Comte

Etablissement Francais Du Sang

Centre Hospitalier Regional Universitaire Besancon

Institut National De La Sante Et De La Recherche Medicale (Inserm)

Centre Hospitalier Régional Universitaire De Besançon

Philippe Saas

Sylvain Perruche

Francis Bonnefoy

Etienne Daguindau

Cécile Chagué

A composition including a supernatant obtained from co-culture of phagocytes with apoptotic cells. The composition is obtained by a) providing phagocytes, b) providing apoptotic cells, c) optionally washing the cells from step a) and b), d) co-culturing the cells of step a) and b), and e) separating the supernatant from the cells. The composition may be used in preventing or treating a pathological immune response.

Cultured phagocyte supernatent compositions

Provided herein is a method for treating or preventing a pathological immune response comprising administering a supernatant obtainable from co-culture of phagocytes with apoptotic cells.

Disease therapy using a tolerogenic pharmaceutical preparation

Growing community of inventors

Besancon, France

Philippe Saas