University of Florida Research Foundation Inc

Technische Unversität Berlin

Centre De Cooperation Internationale En Recherche Agronomique Pour Le Developpement (cirad)

Philippe Rott

Monique Royer

Dean W Gabriel

Julian Kretz

Roderich Suessmuth

Roger Frutos

Stefan Graetz

Dennis Kerwat

Stephane Cociancich

Vivien Schubert

Alexander Pesic

Manuela Huegelland

Antibiotically active compounds characterized by general formula (I), wherein X1, BB, BC, BD, BE and X2 are building blocks with D1, D2, D3, D4 or D5 being linkers which include carbon, sulphur, nitrogen, phosphor and/or oxygen atoms and which are covalently connecting the moities BA and BB, BB and BC, BC and BD, BD and BE and BE and BF, respectively, and wherein in particular the building block BC comprises an amino acid derivative. The compounds for use in a method of treatment of diseases, in particular for use in a method of treatment of bacterial infections are also disclosed.

Albicidin derivatives, their use and synthesis

Three gene clusters that together encode albicidin biosynthesis, the complete gene DNA sequences, and the deduced protein sequences for the enzymes and methods for using the DNA sequences are disclosed and discussed as well as methods for plant protection and creating new antibiotics. The novel Albicidin family of antibiotics is disclosed and their structure deduced.

Biosynthetic genes and host cells for the synthesis of polyketide antibiotics and method of use

Growing community of inventors

Wellington, FL, United States of America

Philippe Rott