Biosphere Medical, Inc.

Biosphere Medical, Sa

Merit Medical Systems, Inc.

Philippe Reb

Celine Chaix

James A Krom

Meriadeg Thomas

Marion Pierre

Barbara De Gioannis

Jim D Mottola

Peter Sutcliffe

Pierre Marion

Franklin J Miller

James Krom

Radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of using the radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of manufacturing radiopaque monomers, polymers, and microspheres are disclosed herein.

Radiopaque monomers, polymers, microspheres, and methods related thereto

Microspheres, compositions including the microspheres, and methods of using the microspheres are disclosed herein. The microspheres can be substantially spherical and can include a copolymer of a monomer (such as an acrylic monomer) and a cyclodextrin or a derivative thereof. The microspheres can also include a therapeutic agent, such as a platinum-based drug.

Microspheres containing therapeutic agents and related methods of use

The present disclosure relates to polymeric materials that may be labeled with a radioisotope, to processes for producing the labeled polymeric material, and to methods of using the materials in analytical and therapeutic applications. Specifically, the disclosure relates to injectable and implantable microparticles, such as microspheres, which are associated with radioisotopes such that the microparticles are both therapeutic and detectable. The radioisotope-containing microparticles are useful for embolization and other therapeutic medical applications.

Compositions and associated methods for radioisotope-binding microparticles

Biomaterials suitable for use as drug eluting, Magnetic Resonance Imaging ('MRI') detectable implants for vascular occlusion are provided, as are methods of producing such biomaterials. Further, methods of treating an individual suffering from a solid tumor are provided.

Biomaterials suitable for use as drug eluting, magnetic resonance imaging detectable implants for vascular occlusion

The present invention relates to compositions and methods for treating diseases and disorders including cancer and various other angiogenic-dependent diseases, vascular malfunctions, arteriovenous malformations (AVM), hemorrhagic processes and treatment of pain, in particular tumor-related pain by drug delivery and/or therapeutic embolization using microspheres. More particularly the invention relates to microspheres containing non-ionic contrast agents, to compositions comprising these microspheres, as well as methods for preparing and using such compositions for embolization therapy. The invention further relates to compositions and methods using detectable microspheres for targeted drug delivery, irrespective of whether embolization is also needed.

Compositions and methods using microspheres and non-ionic contrast agents

Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Also provided are methods of producing microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Further provided herein, for example, are compositions comprising the microspheres and methods of using the microspheres and compositions thereof.

Microspheres useful for therapeutic vascular embolization

Pre-loaded syringes for delivering an embolic agent are disclosed herein. Methods related to syringes pre-loaded with an embolic agent are also disclosed.

Pre-loaded syringes and methods related thereto

An absorbent cleaning device for use during a surgical procedure is disclosed. The absorbent cleaning device may comprise a substantially non-fibrous or non-particulate absorbent material and at least one opening. The opening may comprise a slit or channel and be configured to accommodate a portion of a medical appliance or an elongate medical device. The absorbent cleaning device may be configured to clean the medical appliance or the elongate medical device. The absorbent cleaning device may also be configured to retain or secure a medical appliance or elongate medical device during a surgical procedure.

Growing community of inventors

Themericourt, France

Philippe Reb