Commissariat a L'energie Atomique

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Sanofi Pasteur Inc.

Commissariat a L&prime;energie Atomique

Universite Joseph Fourier De Grenoble

Philippe Peltie

Patrick Pouteau

Magalie Faivre

Anne Planat-Chretien

Patrice Caillat

Thierry Livache

Bruno Flament

Isabelle Texier-Nogues

Dominique David

Viviane Cattin

Franck Vial

Marc Fontecave

Jean-Luc Decout

Vincent Poher

William Fourcault

Marc Cuzin

Frederic Ronzon

Angelo Guiga

Cécile Dueymes

Michel Berger

Frederic Fantoni

Emilie Heinrich

Frédéric Ronzon

Christian Valentin

Rolande Blanc

Frédéric Fantoni

Magali Faivre

Anne Planat Chretien

A method of characterizing the coagulation or sedimentation dynamics of a fluid such as whole blood, a blood fraction, or blood plasma is provided. The method includes illuminating a sample of the fluid with a beam of coherent light; acquiring a time series of images of a speckle pattern generated by interaction between the sample and the spatially coherent light beam; and processing the time series of images. The processing step includes calculating a function representative of the variation in the speckle pattern between two or more images of the series. The invention also provides a device for implementing such a method.

Device for characterizing the coagulation or sedimentation dynamics of a fluid such as blood or blood plasma

A method of characterizing the coagulation or sedimentation dynamics of a fluid such as whole blood, a blood fraction, or blood plasma, the method including: illuminating a sample of the fluid with a beam of coherent light; acquiring a time series of images of a speckle pattern generated by interaction between the sample and the spatially coherent light beam; and processing the time series of images; wherein the processing step includes calculating a function representative of the variation in the speckle pattern between two or more images of the series. The invention also provides a device for implementing such a method.

Method and a device for characterizing the coagulation or sedimentation dynamics of a fluid such as blood or blood plasma

The invention relates to a method for estimating the amount of entities deposited on microparticles in suspension in a solution, and also to an associated device. The method comprises the following steps:

Method for estimating the amount of entities deposited on microparticles in suspension in a solution, associated device and use of said device

The present invention relates to a method of optically imaging at least one biological tissue, in particular to define areas of interest of tissue(s) to be analyzed by tomography. The method according to the invention comprises the following steps:

Method of optically imaging biological tissues by using fluorescence, in particular for defining regions of interest in tissues to be analyzed by tomography

The inventive optical device for measuring the thickness of a medium which is at least partially transparent for an incident beam and covers a second medium comprises a laser for generating the light incident beam in such a way that a beam reflected by the first medium surface and a beam scattered by the second medium surface are formed. The device comprises a photosensitive linear array for detecting the reflected beam and the scattered beam and a processing circuit which is connected to the linear array and enables to measure a space between the reflected beam and the scattered beam and to determine the thickness of the first medium according to the measured space. The processing circuit determines a distance between the linear array and the surface of the second medium from the position of at least one beam and corrects the valve of the thickness of the first medium according to the distance.

Optical device for measuring the thickness of an at least partially transparent medium

An optical device for measuring the displacement velocity of a first movable element in relation to a second element which is fixed to one of said elements and comprises two lasers transmitting two incident beams towards the other elements. The device including photosensitive linear arrays for front and rear detection which are substantially perpendicular to each other. Additional front and rear photosensitive linear arrays are disposed at a distance from the photosensitive front and rear linear arrays. A processing circuit is connected to the photosensitive linear arrays and determines the longitudinal and/or transversal displacement velocity of the movable element. The circuit also determines the distance between the device and the other element by means of optical triangulation and corrects the longitudinal and/or transversal displacement velocity value according of the said distance.

Optical device for measuring the displacement velocity of a first moving element with respect to a second element

This invention relates to an analytical support containing a plurality of oligonucleotides fixed on this support, where each of the nucleotides is marked by a fluorescent compound that presents a variation of fluorescence on the hybridization of each marked oligonucleotide with at complementary oligonucleotide. This support makes it possible to carry out an analysis of biological targets by measuring the variation of fluorescence in order to determine the hybridization of the targets with the oligonucleotides of the support.

Analysis of biological targets using a biochip comprising a fluorescent marker

System for determining the concentration of a substance mixed with a fluorophor, its method of implementation

Chip-based analysis device comprising electrodes with localized heating

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Saint Paul de Varces, France

Philippe Peltie