Université Libre De Bruxelles

Universitéde Liége

Biopteq Sprl

Philippe Neven

Robert Kiss

Didier Cataldo

Didier Serteyn

Jacques Delarge

Véronique Mathieu

Veronique Mathieu

Natacha Rocks

The present invention relates to a process for the purification of curcumin comprising provision of a curcuminoid composition, contacting said curcuminoid composition with basic amino acid or amino acid ester in order to form an amino acid salt of curcumin, separating the salt of curcumin, and recovering curcumin at increased purity levels. Curcumin may be obtained at purity levels beyond 90 wt. %.

Curcumin purification

The present invention relates to the medical field. In a first aspect the present invention relates to novel water soluble cyclodextrin-curcumin complexes having a pharmacological activity, in particular an anti-tumor and/or anti-inflammatory activity, and improved physico-chemical properties. In a second aspect, the present invention relates to a method for preparation of said water soluble curcumin derivatives. The invention further relates in a third aspect to a pharmaceutical composition comprising an effective amount of said water soluble curcumin derivatives. In a fourth aspect, the present invention concerns the use of said water soluble cucumin derivatives as a medicament and the use of said water soluble curcumin derivatives for the preparation of a medicament for the treatment of cancer and inflammatory diseases. In a fifth aspect, the present invention relates to the use of a pharmaceutical composition comprising said water soluble curcumin derivatives in the treatment of cancer and inflammatory diseases and to a new pharmaceutical composition comprising said water soluble curcumin derivatives.

Water soluble curcumin compositions for use in anti-cancer and anti-inflammatory therapy

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Nandrin, Belgium

Philippe Neven