Horiba Abx Sas

Centre National De La Recherche Scientifique

Université De Limoges

Other

Horiba Abx Sas / Horiba Ltd

Philippe Nerin

Gilles Cauet

Benoit Merchez

Patrick Brunel

Alexandra Urankar

Jean-Philippe Gineys

Jerome Bibette

Vincent Couderc

Philippe Leproux

Philippe Roy

Sébastien Fevrier

Didier Cremien

Paul Moreno

Aurelien Daynes

Nelly Rongeat

Didier Lefevre

Pierre-Alain Champert

Sebastien Raimbault

Ludovic Grossard

Jèrôme Bibette

Moustapha Hariche

Sébastien Raimbault

Benoît Merchez

The present invention relates to a flow assay method in a liquid medium for an object (or element) of interest via the formation of aggregates of particles that are surface-functionalized by at least one functionalizing molecule, or receptor, specific for said object of interest.

Flow assay method for an object of interest

The present invention concerns a device for analyzing biological parameters from a sample () comprising (i) first transferring means (), (ii) first preparing means (), (iii) means for measuring cellular components (), (iv) second preparing means () capable of carrying out, on a sample from the first preparing means (), at least one dilution with an assay reagent (R) comprising particles functionalized at the surface with at least one ligand specific to at least one analyte of interest, (v) immunodetection measurement means () capable of assaying at least one analyte of interest by measuring the aggregation of functionalized particles, said device further comprising (i) second transferring means () at least partially separate from the first transferring means () and (ii) means for applying a magnetic field () capable of causing, by magnetic interaction, an acceleration of the aggregation of said functionalized particles, which comprise magnetic colloidal particles. The invention also concerns a method implemented in said device.

Device and method for carrying out haematological and biochemical measurements from a biological sample

The present invention relates to a method for compensating for the breakdown of a reagent stored in an aqueous phase comprising at least one fluorescent compound and enabling the identification of particles, including the steps of: (i) measuring the fluorescence level FLUOm(t) of particles marked with said reagent; (ii) measuring the absorbance at at least one wavelength of a solution of said reagent, at a time t close to the time of said fluorescence level FLUOm(t) measurements, so as to determine at least one current optical density DO(t) of the reagent; and (iii) calculating a correction of the fluorescent level measurements using said at least one current optical density DO(t) and at least one initial optical density DO(0) of the reagent that has not been broken down. The invention also relates to a biological analysis device implementing the method.

Method for compensating for the aging of a reagent during fluorescence measurements carried out on particles, and biological analysis device implementing the method

A device for inspecting a biological fluid, including a channel through which the fluid flows, a first inspection module arranged in a first region of the channel, and a second inspection module arranged in a second region of the channel, the device configured to provide a quantity that is representative of output of the second inspection module. The first inspection module is configured to measure at least one electrical property of the fluid passing through the first region. The second inspection module is configured to measure at least one optical property of the fluid passing through the second region. The inspection device also includes a controller connected to the first inspection module and to the second inspection module and configured to control the second inspection module according to the output of the first inspection module.

Device for inspecting a biological fluid

The invention relates to a method of classifying and flow measuring the refringence of at least two populations of particles present in a fluid. The method uses a light source that has small coherence time, with a coherence length Lc&#x3c;100 &#x3bc;m, that is used under extinction conditions at a center wavelength selected as a function of a range of volumes and of a range of refractive indices expected for the particles under consideration. The method uses a device that, together with the light source, forms a converging illuminating beam of aperture angle that is selected as a function of the range of volumes and the range of refractive indices expected for the particles under consideration at the selected center wavelength.

Device and method for multiparameter measurements of microparticles in a fluid

The invention relaters to a device () for biological analysis by measurement of photoluminescence in a fluid in a measurement tank (). This device () comprises at least two light sources () adapted to emit in different spectral areas respectively appropriate for measurement of absorption and fluorescence, and a sensor device () comprising a sensor (), an optical system (), and filter means (), which three elements are mutualized in accordance with the invention to enable absorption and/or fluorescence to be measured. In accordance with the invention the internal gain of the sensor () is configurable to enable the fluorescence and absorption measurements to be executed sequentially.

Electrooptic measurement device and method intended for classifying and counting microscopic elements

The invention concerns a device (DA) for analyzing microscopic elements, comprising firstly a measuring space (CM) for microscopic elements to be analyzed, secondly at least one source (S) delivering conjugated rays at the measuring space (CM), having at least two different analyzing wavelengths and designed to interact with the microscopic elements in the measuring space (CM) to form interacting rays, thirdly coding means (M) for encoding the rays upstream of the measuring space (CM) with different codes, fourthly optical filtering means (FO) for selectively filtering the interacting rays of fluorescence and/or diffusion depending on their wavelength, fifthly detecting means (DE, DF) for transforming into electric signals part at least of the interacting rays from the measuring space (CM), and sixthly analyzing means (MA) including decoding means (DRE, DRF) for decoding the electric signals to enable data representing the analyzed microscopic elements to be determined.

Device and method for multiparametric analysis of microscopic elements

A dedicated polychromatic light generating device including optical pumping devices used to deliver radiation with at least two different excitation wavelengths and a light-guiding device used to deliver polychromatic light at an output when excited by the radiation in a non-linear interaction regime.

Device for generating polychromatic light with a continuous spectrum

An optical device for examining a fluid including a measuring space including a compulsory passage for the fluid to be examined, at least one source delivering a selected light to an optical illuminator serving to collect at least part of the light having traversed the compulsory passage and to deliver the selected light to analyze the collected light so as to deliver signals representing data borne by the collected light. The optical illuminator includes a first light guide including one end, opposite the source, and configured to deliver the light, derived from the source, in accordance with a selected geometry to illuminate the compulsory passage in a substantially uniform manner and under a substantially constant intensity.

Device for examining a fluid by uniform illumination using a configured light guide

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Montpellier, France

Philippe Nerin