Laboratoires Expanscience

Laboratories Expanscience

Laboratoire Expanscience

Laboratoires Pharmascience

Philippe Msika

Antoine Piccirilli

Nathalie Piccardi

Caroline Baudouin

Stéphanie Bredif

François Paul

Jacques Legrand

Sophie Leclere-Bienfait

Alex Saunois

Sebastien Garnier

Stephanie Bredif

Sébastien Garnier

Caroline Baudoin

Joachim Fluhr

Jean-Christophe Choulot

Sebastien Debrock

Franck Menu

Nadège Lachmann

Karim Boumediene

Jean-Pierre Pujol

Georges Bernard Guillou

Chafik Ghayor

Francois Paul

Dalale Naaimi

Nicole Broutin

Nathalie Petit

Patricia Ferraris

Delphine Ribes

Jocelyne Hilaire

Isabelle Grondin

Nadege Lachman

Dalale Naaïmi

Carole Kohler

Marisa Meloni

Nadege Lachmann

David Daguet

Jacqueline Smadja

Nadège Lachman

Sophie Leclere- Bienfait

Stéphanie BRÉDIF

Sébastien Debrock

The invention relates to an extract of aerial parts of Maca rich in polyphenols, and also to a composition comprising such an extract and, where appropriate, a suitable excipient. The invention also relates to a process for extracting an extract of aerial parts of Maca rich in polyphenols, and also to the extract that can be obtained by means of said process. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths and/or for use thereof in preventing and/or treating vascular disorders. Finally, the invention relates to a cosmetic care process for the skin, the superficial body growths or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which comprises the administration of such a composition or of such an extract.

Extract of aerial parts of Maca rich in polyphenols and composition comprising same

The invention relates to an avocado extract rich in polyphenols, containing at least 10% by weight of polyphenols, expressed in gallic acid equivalent relative to the dry extract obtained, wherein said polyphenols contain procyanidins, cafeic acid and cafeic acid derivatives, typically in a proportion of at least 70% by weight, expressed in gallic acid equivalent relative to the total polyphenol content by weight. The invention also relates to a composition comprising an extract according to the invention as active agent and a suitable excipient. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths. Finally, the invention relates to a cosmetic care process for the skin, the superficial body growths or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which consists in administering such a composition or such an extract.

Avocado flesh and/or skin extract rich in polyphenols and cosmetic, dermatological and nutraceutical compositions comprising same

The invention relates to a composition comprising an extract of passionflower seeds, and preferentiallyseeds. The composition is advantageously cosmetic, pharmaceutical, dermatological or nutraceutical. The subject matter of the invention is also a process for extracting an extract of passionflower seeds and preferentiallyseeds, and also the extract which can be obtained by means of said process. The invention also relates to such a composition or such an extract for use in the prevention or treatment of disorders or pathological conditions of the skin, of the mucous membranes or of the skin appendages, for use in the prevention or treatment of vascular disorders, for use for combating oxidative stress, or else for use in the prevention or treatment of adipose tissue modifications. Finally, the invention relates to a cosmetic care process for the skin, the skin appendages or the mucous membranes, with a view to improving, the condition thereof or the appearance thereof, consisting in administering such a composition or such an extract.

Extract of passionflower seeds and cosmetic, pharmaceutical, dermatological and nutraceutical compositions comprising same

The invention relates to biomarkers of the skin of children and, in particular, that of infants, having altered expression in the presence of urine. Such markers are particularly advantageous as they allow the skin's response to urine to be monitored. The inventors have developed methods for evaluating the efficacy in vitro of formulations in preventing the harmful effects of urine on a child's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.

Method for evaluating the harmful effects of urine on children's skin

The present invention relates to a method for determining the isotropy of the skin surface of a subject, and hence the degree of maturation of the said skin surface, by examining various parameters reflecting the cell organization. Methods for identifying active agents, raw materials and formulation are also provided.

Surface isotropy as a marker for epidermal maturation

The present invention relates to the use of a lupin peptide extract to prevent loss of skin firmness or to increase the firmness of skin. Advantageously, the lupin peptide extract can prevent the appearance of cellulite and/or reduce skin cellulite.

Lupin peptide extracts and skin firmness

The present invention relates to a method for determining the relief of the skin surface of a subject, and hence the degree of maturation of the said skin surface. Methods for identifying active agents, raw materials and formulation are also provided.

Skin topography as a marker for skin maturation

A method for determining whether the skin surface of a subject is mature/immature in its organization/function, by taking a skin sample and determining the corneodesmosome distribution within theof the sample by an immunoelectron microscopy method.

Corneodesomosomes and barrier function maturation

A skin model comprises keratinocytes capable of overexpressing filaggrin. A method for evaluating the in vitro activity of a formulation or of at least one active agent on the healing of nipple skin and/or on the reduction of nipple skin inflammation, by bringing said active agent or said formulation into contact with a skin model comprising keratinocytes overexpressing filaggrin and also comprising a lesion, and measuring the level of production of at least one biological marker chosen from lactate dehydrogenase (LDH), TNF&#x3b1;, filaggrin, TGF&#x3b2;1 and &#x3b2;1 integrin.

Reconstituted nipple skin model

The invention relates to a method for evaluating the effectiveness of an active ingredient selected from C7 avocado sugars, also called avocado perseose, for preventing or treating a deficiency of the skin barrier, said method comprising the determination of the level of expression and/or activation of at least one biological marker, where said biological marker is selected from epidermal maturation markers, lipid barrier markers, hydric regulation markers andregulation markers.

Use of biomarkers for evaluating the effectiveness of active ingredients

The present invention relates to the use of a peptide and glycoside extract offruit as a cutaneous neurosensory agent, for improving the response of the cutaneous neurosensory system, in particular for: &#x2014;improving cutaneous innervation in the basal state, &#x2014;combatting age-related loss of cutaneous innervation in the basal state, advantageously for preventing loss of the cutaneous sensitivity and/or combatting thinning of the epidermis, and/or &#x2014;improving cutaneous perception of the environment, more particularly for combatting burns, extreme cold and/or pain.

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The invention concerns a use of C7 sugars and derivatives of formula (I), called avocado perseose, which have, inter alia, a protective activity to epidermal skin cells. These C7 sugars and derivatives are capable of maintaining the expression of markers of adult stem cells, in particular basal stem cells. Avocado perseose can also be used for preventing the deleterious effects of environmental damage. Avocado perseose has a beneficial effect on the conservation of the potential of epidermal stem cells and thus helps maintain skin homeostasis.

Use of a composition comprising avocado perseose in the protection of epidermal stem cells

The invention relates to in vitro methods for testing formulations or active ingredients for preventing the harmful effects of UV on children's skin, in particular children aged three or less. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the harmful effects of UV on the skin of children aged three or less, using a skin model specifically capable of reproducing the characteristics of the skin of children of this age.

Method for evaluating the harmful effects of UV on children's skin

The present invention relates to a composition including at least one C7 sugar, or derivative from esterification of said sugar, and a pharmaceutically acceptable carrier for treating alopecia. The present invention also relates to a method for cosmetically treating hair and nails, said method being intended to stimulate the growth thereof and/or slow the loss thereof. According to said method, a cosmetic composition including at least one C7 sugar, or derivative from esterification of said sugar, is administered. The present invention finally relates to a method for cosmetic care of hair and/or eyelashes and/or nails.

Composition containing at least one C7 sugar for alopecia treatment, cosmetic treatment of hair and nails, and care of hair, eyelashes or nails

Growing community of inventors

Versailles, France

Philippe Msika