Roussel Uclaf

Hoechst Marion Roussel

Philippe Mackiewicz

Jean-Yves Godard

Christian Richard

Luc Devocelle

Jean Buendia

Denis Prat

Francois Clemence

Francoise Delevallee

Michel Delthil

Raphael Bouchet

Daniel Guilmard

Claudine Maushart

Phenylimidazolidine preparation process

A compound of the formula ##STR1## wherein R is hydrogen or an ester remainder, X is hydrogen or fluorine and Y combined with the doted lines represents ##STR2## or X is hydrogen and and Y combined with the dotted lines is ##STR3## and R.sub.1 is the remainder of an enol ether or ester.

Intermediates for the preparation of 6.alpha., 9.alpha.-difluoro steroids

A process for the preparation of 6.alpha.,9.alpha.-difluoro steroids of the formula ##STR1## wherein R is hydrogen or an ester remainder.

Preparation of 6.alpha., 9.alpha.-difluoro steroids

Mixtures of compounds of ##STR1## or a mixture of the latter and a compound of the formula ##STR2## which are useful intermediates for the preparation 20-keto-21(S)-hydroxy steroids.

Preparation process for 20-keto 21(S) hydroxy steroids compounds and

A compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, acyl of an organic carboxylic acid of 1 to 8 carbon atoms, allyloxycarbonyl, alkoxycarbonyl and aralkoxycarbonyl of up to 8 carbon atoms and alkylsulfonyl and arylsulfonyl of up to 8 carbon atoms and their use to prepare substituted 16,17-methylenedioxy-steroids and novel intermediates.

Lambda-1,4-pregnadiene-3,20-diones

.delta..sup.1,4 -pregnadiene-3,20-diones

An improved process for the preparation of 20-keto-21(S)-hydroxy steroids of the Formula ##STR1## wherein R.sub.1 is alkyl of 1 to 3 carbon atoms, R.sub.2 is alkyl of 1 to 12 carbon atoms, and R.sub.3 is alkyl of 1 to 4 carbon atoms and novel intermediates therefrom.

Preparation process for 20-keto-21(S) hydroxy steroid compounds and

A compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, acyl of an organic carboxylic acid of 1 to 8 carbon atoms, allyloxycarbonyl, alkoxycarbonyl and aralkoxycarbonyl of up to 8 carbon atoms and alkylsulfonyl and arylsulfonyl of up to 8 carbon atoms and their use to prepare substituted 16,17-methylenedioxysteroids and novel intermediates.

Process for preparing .DELTA..sup.1,4 -pregnadiene-3,20-diones

A novel process for the preparation of 4H-1,2,4-triazoles in their racemic or optically active forms of the formula ##STR1## wherein the compounds have analgesic activity.

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Livry Gargan, France

Philippe Mackiewicz