Cephalon, Inc.

Cephalon France

Cephelon France

Teva Sante

Philippe Louvet

Brigitte Lesur

Edward R Bacon

Sankar Chatterjee

Mohamed A Iqbal

Dominique Schweizer

Rabindranath Tripathy

Derek D Dunn

Greg A Hostetler

Christophe Yue

Olivier Neckebrock

Marie-Edith Gourdel

Eric Riguet

Mohamed Iqbal

The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith.

Bicyclic aromatic sulfinyl derivatives

The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: wherein Ar, Y, Rare as defined in claim

Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation

The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A): wherein Ar, X, Y, R, R, R, and q are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness, promotion of wakefulness, treatment of Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, treatment of attention deficit hyperactivity disorder ('ADHD'), enhancing function in disorders associated with hypofunctionality of the cerebral cortex, including, but not limited to, depression, schizophrenia, fatigue, in particular, fatigue associated with neurologic disease, such as multiple sclerosis, chronic fatigue syndrome, and improvement of cognitive dysfunction.

Thio-substituted arylmethanesulfinyl derivatives

The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted biaryl-methanesulfinyl acetamides of Formula (I): wherein Ar, Y, R, R, R, R, q and x are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness associated with narcolepsy, obstructive sleep apnea, or shift work disorder; Parkinson's disease; Alzheimer's disease; attention deficit disorder; attention deficit hyperactivity disorder; depression; or fatigue associated with a neurological disease; as well as the promotion of wakefulness.

Thio-substituted biarylmethanesulfinyl derivatives

Thio-substituted biaryl-methanesulfinyl derivatives

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Montgeron, France

Philippe Louvet