Virginia Commonwealth University

Philippe Lam

Gary E Wnek

Gary L Bowlin

Marcus E Carr, Jr

David Simpson

Helen L Fillmore

The invention is directed to formation and use of electroprocessed fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed fibrin may also be combined with other molecules in order to deliver the molecules to the site of application or implantation of the electroprocessed fibrin. The fibrin or fibrin/cell suspension is electrodeposited onto a substrate to form the tissues and organs.

Electroprocessed fibrin-based matrices and tissues

The invention is directed to use of fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or &ldquo;organ-like&rdquo; tissue. A preferred embodiment is a plasma-derived fibrin matrix containing cells.

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San Bruno, CA, United States of America

Philippe Lam