Delalande S.a.

Farmitalia Carlo Erba S.r.l.

Inverni Della Beffa Spa

Societe De Recherches Industrielles Sori

Centre D'etudes Experimentals Et Cliniques De Pharmacologie Et

Pharmacia & Upjohn

Philippe Dostert

Franco Heidempergher

Mario Varasi

Paolo Pevarello

Alberto Bonsignori

Romeo Roncucci

Philippe L Dostert

Guy R Bourgery

Michel Langlois

Bernard P Bucher

Colette A Douzon

Alain P Lacour

Patrick G Guerret

Thierry F Imbert

Jean-Francois R Ancher

Gerard H Moinet

Gisele C Mocquet

Margherita Strolin-Benedetti

Bruno Gabetta

Maria J Magistretti

Jean A Coston

Claude G Gouret

Piero Melloni

Claude J Gouret

Patrice Renaut

Henri Laborit

Arturo D Torre

Robert Zerbib

Alain L Nedelec

Michel Maumy

Patrice J Capdevielle

Jean-Alain Coston

Jean-Francois Rumigny

Alain-Rene Schoofs

N-phenylalkyl substituted .alpha.-amino carboxamide derivatives of formula (I) ##STR1## wherein R is C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.8 cycloalkyl, furyl, thienyl, pyridyl or unsubstituted or substituted phenyl; A is a --(CH.sub.2).sub.m -- or --(CH.sub.2).sub.p --X--(CH.sub.2).sub.q -- group wherein X is --O--, --S-- or --NR.sub.4 --; R.sub.1, R.sub.2, R.sub.3, R'.sub.3, R.sub.4, n, m, p and q are as herein defined; and each of R.sub.5 and R.sub.6 is independently hydrogen or C.sub.1 -C.sub.6 alkyl, and the pharmaceutically acceptable salts thereof, are active on the central nervous system and can be used as anti-epileptic, anti-Parkinson, neuroprotective, antidepressant, antispastic and/or hypnotic agents in mammals.

N-phenylalkyl substituted .alpha.-amino carboxamide derivatives and

The invention provides new compounds of formula (I) ##STR1## wherein n is an integer of 1 to 4; each of R and R.sub.1, which may be the same or different, is hydrogen, halogen, trifluoromethyl or C.sub.1 -C.sub.4 alkoxy; R2 is hydrogen or C.sub.1 -C.sub.4 alkyl; and a pharmaceutically acceptable salts thereof; and wherein when, at the same time, R is hydrogen, R.sub.1 is hydrogen or halogen and n is one, then R.sub.2 is other than hydrogen or methyl; and of formula (IA) ##STR2## wherein R.sub.3 is halogen, and a pharmaceutical acceptable salt thereof, which are active on the central nervous system (CNS) and can be used in therapy as anti-epileptics, anti-Parkinson, neuroprotective, antidepressant, anti-spastic and hypnotic agents.

Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and

The invention provides new compounds of formula (I) ##STR1## wherein, subject to a proviso, n is zero or an integer of 1 to 3; each of R and R.sub.1, which may be the same or different, is hydrogen, halogen, trifluoromethyl or C.sub.1 -C.sub.4 alkoxy; R.sub.2 is hydrogen or C.sub.1 -C.sub.4 alkyl optionally substituted by hydroxy; each of R.sub.3 and R.sub.4 independently is hydrogen or C.sub.1 -C.sub.4 alkyl; or a pharmaceutically acceptable salt thereof; and of formula (IA) ##STR2## wherein R.sub.5 is hydrogen, halogen, trifluoromethyl or C.sub.1 -C.sub.4 alkoxy, or a pharmaceutically acceptable salt thereof, which are active on the central nervous system (CNS) and can be used in therapy as anti-epileptics, anti-Parkinson, neuroprotective, antidepressant, anti-spastic and hypnotic agents.

Substituted (arylalkoxybenzyl)aminopropanamide derivatives and process

Cyclic amido alcohols of formula I are useful in the treatment of neurological and psychiatric disorders.

Preparation of novel amido-alcohol derivatives and their therapeutic uses

Aryloxy-, arylthio-, heteroaryloxy-, heteroarylthio-alkenylene

There is described a process for preparing proanthocyanidine A2 by extraction from cortex or fruits of Aesculus hippocastanum and related species and its activity for stimulating healing processes, e.g. healing wounds and injuries of various origins, gastric and duodenal ulcers for modifying conditions of impaired capillary permeability and resistance and for obtaining an anti-lipid peroxidation effect. There are also described pharmaceutical formulations suitable for use by topical and systemic routes.

Therapeutic use of proanthocyanidine A2 as a cytoprotective agent

A mixture of the 4 stereoisomers of formula (I) below, each of the pairs of corresponding racemic diastereoisomers and each of the enantiomers corresponding to each pair, that is to say each of said stereoisomers: ##STR1## in which R.sub.1 represents: a hydrogen atom,

5-aminoethyloxazolidin-2-one derivatives

Process for obtaining proanthocyanidine A2, pharmaceutical compositions

N-arylated oxazolidine-2-one derivatives corresponding to the formula: ##STR1## and of S(+) configuration, A representing in this case the hydroxyl radical or of R (+) configuration, A designating then the N-methylamino group, as well as the acid addition salts thereof. Application in therapeutics more particularly as monoamine oxidase inhibitors.

Optically active derivatives of N-arylated oxazolidine-2-one, the

There are disclosed nor-tropane derivatives substituted at the 3 position with aroylamino or heteroaroylamino and substituted at the 8 position with benzyl, substituted benzyl, 2-methyl thiophene, 3-methyl thiophene, 2-methyl furan or cyclohexylmethyl. The compounds are prepared by condensing the carboxylic acids corresponding to said aroyl or heteroaroyl group with the corresponding .beta.-3-amino-8-substituted nor-tropanes. The compounds possess neuroleptic properties.

4-Amino-5-bromo-2-methoxy-N-[8-(benzyl)]-8-azabicyclo[3.2.1]

A compound of the formula ##STR1## where R is selected from the group consisting of CH.sub.3 --CO--(CH.sub.2).sub.2 --O--, ##STR2## The compounds are useful in treating depression.

-N-substituted phenyl-5-methoxymethyl-2-oxazolidinones and

The present invention concerns novel heterocyclic aminoalcoyl derivatives having the formula: ##STR1## wherein n=1, 2 or 3; A represents a nitrogen atom or the CH group, X=CH.sub.2 or CH.sub.2 O; R represents a phenyl nucleus possibly substituted; NR.sub.1 R.sub.2 =amino, methylamino, N,N-dialkylamino or an heterocyclic radical; and R.sub.3 =H, halogen, alkyl, alkyloxy or methoxy. These derivatives are useful as drugs, especially as analgesics and antidepressants.

3-Hydroxyalkyl-3,4-dihydro-1-substituted isoquinolines

Process for preparing a para-quinone or ortho-quinone derivative, possibly alkoxylated or aryloxylated, which consists in oxidizing respectively the corresponding hydroquinone or pyrocatechic derivative, by means of the complex prepared, in situ or separately, by combining a cuprous salt, a hydrocarbon substituted by a cyano group and molecular oxygen, the oxidation being possibly carried out in the presence of an alkoxylating or aryloxylating agent of the hydroxylated derivative type.

Process for preparing para-quinone or ortho-quinone derivatives,

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Paris, France

Philippe L Dostert