Laboratoire Francais Du Fractionnement Et Des Biotechnologies

Sonaca S.a.

Etat Francais Represente Par Le Directeur Central Du Service De Sante Des Armees

Philippe Klein

Christophe De Romeuf

Emmanuel Nony

Nicolas Bihoreau

Dominique Bourel

Christine Gaucher

Sylvie Jorieux

Christian Behrens

Dimitri Gueuning

Bernard Poulaert

Denis Hoguet

Christine Gauchet

The present invention relates to a class-G immunoglobulin against the anthrax toxin protective antigen (PA), or one of the fragments of same, comprising at least: a variable heavy-chain region comprising an amino acid sequence represented by the sequence SEQ ID NO: 1, or comprising an amino acid sequence having at least 90% identity with the sequence SEQ ID NO: 1, and comprising the amino acids Leucine in position 51 and Glycine in position 67, and a variable light-chain region comprising an amino acid sequence represented by the sequence SEQ ID NO: 2, or comprising an amino acid sequence having at least 90% identity with the sequence SEQ ID NO: 2, and comprising a Leucine amino acid in position 55. The invention also relates to the uses of such an immunoglobulin.

Immunoglobulin against the anthrax toxin

The invention concerns the use of human or humanized chimeric monoclonal antibodies which are produced in selected cell lines, said antibodies bringing about a high ADCC activity as well as a high secretion of cytokines and interleukins, for treating underpopulations of so-called weak-response patients exhibiting CD16 FCGR3A-158F homozygote or FCGR3A-158V/F heterozygote polymorphism.

Use of ADCC-optimized antibodies for treating low-responder patients

The invention relates to a process for manufacturing a sandwich panel comprising a step to bake a stacked structure () provided with: a honeycomb body (); a film () pre-impregnated with a first resin with a polymerization temperature T; and a first stack () of fiber layers pre-impregnated with a second resin with a polymerization temperature Tgreater than T, the film being arranged between the first stack and the body. The baking step comprises a first phase designed to use the film (), to create a rigid barrier providing a seal from the second resin by polymerization of said first resin, followed by a second phase designed to produce the skin starting from the stack (), by polymerization of the second resin.

Process for manufacturing a panel comprising at least one honeycomb body and a first skin made from a composite material

Use of ADCC-optimized antibodies for treating weak patients

Growing community of inventors

Lille, France

Philippe Klein