Columbia Laboratories, Inc.

Smith & Nephew Richards Inc.

Philippe J Cartier

William J Bologna

Howard L Levine

Dominique De Ziegler

Thomas Andrew Carls

David Lee Evans

John K Steele

William Kennedy

James Andrews

Carol D Taylor

A bioadhesive controlled, extended release progressive hydration composition wherein the active ingredient may be protected from water or the surrounding environment, thereby protecting it from metabolism or from other degradation caused by moisture, enzymes, or pH effects, and making it bioavailable only at a controlled rate. The active ingredient may be protected from moisture during the manufacturing process, as necessary or desired, and more importantly may be protected from moisture and the immediate septic environment until well after the patient has applied the composition, and then only at a slow and controlled rate. It is by this process of progressive hydration that the active ingredient remains protected for many hours after administration. It is also by the process of progressive hydration that controlled and sustained release is achieved because only that part of the active ingredient that is the hydrated (aqueous) fraction of the composition is available for absorption (bioavailable).

Bioadhesive progressive hydration tablets

A bioadhesive tablet wherein the active ingredient may be protected from water or the surrounding environment, thereby protecting it from metabolism or from other degradation caused by moisture, enzymes, or pH effects, and making it bioavailable only at a controlled rate. The active ingredient may be protected from moisture during the manufacturing process and more importantly may be protected from moisture and the immediate septic environment until after the patient has applied the tablet, and then only at a slow and controlled rate. It is by this process of progressive hydration that the active ingredient remains protected for many hours after administration. It is also by the process of progressive hydration that controlled and sustained release is achieved because only that part of the active ingredient that is the hydrated (aqueous) fraction of the tablet is available for absorption (bioavailable).

Bioadhesive progressive hydration tablets and methods of making and using the same

A surgical instrument for shaping the distal femur of a patient to receive a unicondylar prosthetic component includes a cutting guide body that carries a pair of cylindrically shaped openings in the guide body, each of the openings having a central longitudinal axis and the respective axes of the openings forming an acute angle. An annular bushing is removably received in a selected one of the cylindrical openings during a cutting of the distal femur. A bone cutting reamer registers with a central cylindrical opening in the bushing. The bone cutting reamer has an annular shoulder that abuts the top of the bushing to define the depth of cut. During use, the surgeon positions the cutting guide body over a diseased condyle of the patient's distal femur. The surgeon then sequentially places the bushing and its associated bone cutting reamer into one of the selected openings of the cutting guide body. After placing the bone cutting reamer in the second opening of the guide body, the surgeon has formed two overlapping circular cuts which form an elongated oval shaped and three-dimensionally convex surface for receiving the unicondylar prosthesis.

Uni-compartmental femoral knee instruments and prosthesis

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Paris, France

Philippe J Cartier