Dupont Nutrition Biosciences Aps

Danisco A/s

Universite Laval (canada)

Danisco France

Philippe Horvath

Christophe Fremaux

Dennis A Romero

Rodolphe Barrangou

Patrick Boyaval

Pascal Fourcassie

Elise Manoury

W Michael Russell

Pascal Hols

Laetitia Fontaine

Sylvain Moineau

Alexander Hynes

Geneviève Rousseau

Joshua K Young

Sonia Huppert

Anne M Millen

Joachim Schwobe

Lindsay L Traeger

Marie-Laurence Lemay

Methods and compositions are provided for the use of anti-CRISPR (ACR) proteins in plants, including modulation of Cas endonuclease activity, improvement of frequency of homologous recombination, control of Cas endonuclease activity during various cell cycles, spatial and/or temporal regulation of Cas endonuclease activity in plants, usage in gene activation or repression, as well as reduction of off-target polynucleotide cleavage.

Anti-CRISPR polynucleotides and polypeptides and methods of use

The invention relates to anti-CRISPR genes and anti-CRISPR proteins, and their uses in various biotechnology applications.

Anti-CRISPR genes and proteins and methods of use

The invention relates to CRISPR sequences found in bifidobacteria and their uses.

Bifidobacteria CRISPR sequences

The present invention relates to the use of one or more cas genes for modulating resistance in a cell against a target nucleic acid or a transcription product thereof.

Method of modulating cell resistance

The present invention relates tostrains, usable as starter cultures, able to provide both satisfactory rheological and organoleptic properties, and satisfactory shelf life to the media into which they are incorporated. In particular, these strains are also bacteriophage-resistant, thereby minimizing bacteriophage infection. The invention also provides a composition comprising one of thesestrains, and feed or food products obtained with these strains.

strains

The invention relates to bacterial strains having an outstanding ability to produce menaquinone and to applications thereof.

Bacterial strains having an outstanding ability to produce menaquinone

The disclosure relates in one aspect to a fast acidifying lactic acid bacterium that generates a viscosity in fermented milk greater than about 62 Pa&#xb7;s after 14 days of storage at 6&#xb0; C. Further, the disclosure includes method for preparing and products of food, food additive, feed, nutritional supplement, or probiotic supplement, thereof.

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The present invention relates to a nucleic acid comprising aCRISPR repeat region and/or aCRISPR spacer region.

Method for modulating resistance

The present invention provides methods for tagging and/or identifying microorganisms. In some preferred embodiments, the microorganisms are bacteria. In some particularly preferred embodiments, the bacteria are members of the genus, while in other embodiments, the bacteria are members of other genera. The present invention also provides microorganisms tagged using the methods set forth herein. In some preferred embodiments, the tagged microorganisms are bacteria. In some particularly preferred embodiments, the tagged bacteria are members of the genus, while in other embodiments, the tagged bacteria are members of other genera.

Tagged microorganisms and methods of tagging

The present invention relates to peptides, nucleic acids and methods for transforming a bacterium belonging to thegenus by natural competence and their use in the food and feed industry.

The invention relates to a genetic cluster of strains of, wherein the milk fermented with said strains is highly viscous and weakly ropy. The invention also relates to a genetic cluster of strains of, wherein the genome of said strains comprises a CRISPR locus having the nucleotide sequence of SEQ ID N&#xb0; 1.

Genetic cluster of strains of streptococcus thermophilus having unique rheological properties for dairy fermentation

The invention relates to a genetic cluster of strains of, wherein the milk fermented with said strains is highly viscous and weakly ropy. The invention also relates to a genetic cluster of strains of, wherein the genome of said strains comprises a CRISPR locus having the nucleotide sequence of SEQ ID No 1.

Growing community of inventors

Saint-Gervais-les-3-Clochers, France

Philippe Horvath