Institut De Recherche Pour Le Developpement (ird)

Centre De Cooperation Internationale En Recherche Agronomique Pour Le Development (cirad)

Institut De Recherche Pour Le Developpement

Philippe Holzmuller

Jean-Loup Lemesre

Denis Sereno

Philippe Vincendeau

Silla Semballa

Gerard Cuny

Mireille Cavaleyra

Rachel Bras-Gonçalves

The invention relates to an antigenic structure that contains a tryptophan epitope, characterised in that said structure is made up of a tryptophan pattern W or a peptide of 3 or 4 amino acids comprising a pattern W, coupled with glutaraldehyde. The invention can he used for screening trypanosomiasis in humans or animals.

Antigenic structure and uses thereof for screening trypanosomiases in humans and animals

The invention relates to nucleic acid constructions, characterized in that they comprise nucleic acids which are isolated in the sense position and which are capable of coding for an immunogenic protein of promastigotes or amastigotes of, said nucleic acids responding to one of the sequences SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, SEQ ID No. 4, SEQ ID No. 5 et SEQ ID No. 11 and coding for a protein respectively exhibiting a sequence SEQ ID No. 6, SEQ ID No. 7, SEQ ID No. 8, SEQ ID No. 9, SEQ ID No. 10 et SEQ ID No. 12. The invention can be used for over-expression of the genes ofcoding for an excretion/secretion antigen.

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The invention relates to an expression vector of a gene coding for an antigenic protein ofpromastigote, characterized in that it comprises a PSA gene insert in opposite orientation. The invention can be applied to the development of mutants under-expressing, or no longer expressing, genes coding for an antigenic protein ofpromastigote, and to the therapeutic and/or vaccine-oriented uses thereof.

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Poussan, France

Philippe Holzmuller