Idorsia Pharmaceuticals Ltd

Actelion Pharmaceuticals Ltd

Philippe Guerry

Francois Lehembre

Julien Pothier

Hamed Aissaoui

Sylvia Richard-Bildstein

Heinz Fretz

Thierry Kimmerlin

Hervé Siendt

Laetitia Pouzol

Anja Valdenaire

Shuguang Yuan

Markus Gude

Markus Von Raumer

Thomas Pfeifer

Herve Siendt

The invention relates to crystalline forms of (3S,4S)-1-Cyclopropylmethyl-4-{[5-(2,4-difluoro-phenyl)-isoxazole-3-carbonyl]-amino}-piperidine-3-carboxylic acid (1-pyrimidin-2-yl-cyclopropyl)-amide; processes for the preparation thereof, pharmaceutical compositions containing such crystalline forms, pharmaceutical compositions prepared from such crystalline forms, and their use as a medicament, especially as CXCR7 receptor modulators.

Crystalline forms of the CXCR7 receptor antagonist (3S,4S)-1-Cyclopropylmethyl-4-{[5-(2,4-difluoro-phenyl)-isoxazole-3-carbonyl]-amino}-piperidine-3-carboxylic acid (1-pyrimidin-2-yl-cyclopropyl)-amide

The present invention relates to piperidine derivatives of formula (I) wherein Ar, Ar, R, R, R, and Rare as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.

Piperidine CXCR7 receptor modulators

The present invention relates to piperidine derivatives of formula (I) wherein Ar, Ar, R, R, Rand Rare as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.

Piperdine CXCR7 receptor modulators

The present invention relates to derivatives of formula (I) wherein (R), ring (A), Y, Y, X, R, L, L, and Arare as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.

CXCR7 receptor modulators

The present invention relates to derivatives of formula (I) wherein (R), R, R, R, R, R, L, L, X, Y and Arare as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.

The present invention relates to 1-[m-carboxamido(hetero)aryl-methyl]-heterocycyl-carboxamide compounds of formula (I) 

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Allschwil, Switzerland

Philippe Guerry