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Institut National De La Sante Et De La Recherche Medicale

Urban, Stephan

Sylvie Rumin

Christiane Guguen-Guillouzo

Philippe Gripon

Christian Trepo

Stephan Urban

The invention relates to a group of synthetic polypeptides, derived from the pre-S1 region of HBV, that efficiently interfere with early steps of an HBV infection. The peptides of the invention can be used in diagnostics for the detection of antigens and/or antibodies.

Hepatitis B virus pre-S1 derived synthetic polypeptides and uses thereof

Human hepatoma cell lines are provided that comprises a set of cells clonally derived from a cancerous human liver cell, in which each cell of the set expresses a receptor having an affinity for binding a virus of thegenus and a virus of thegenus to enable infection by viruses of both genus in native forms, and in which each cell of the set exhibits susceptibility to infection by a hepatotropic parasite of thegenus in a native form. Various compositions and methods relating to diagnostic, therapeutic, and prophylactic embodiments are also provided.

Human hepatoma lines, methods for obtaining same and uses thereof

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Rennes, France

Philippe Gripon