Merck Patent Gesellschaft MIT Beschrankter Haftung

Lipha

Merck Patent Gmbh

Merck Patent Gesellschaft MIT

Lipha, Lyonnaise Industrielle Pharmaceutique

Philippe Durbin

Daniel Guerrier

Francois Collonges

Herve Dumas

Claude Lardy

Michel Brunet

Marc Noblet

Jaques Barbanton

Jean Jacques Berthelon

Trong Nghia Luong

Yves Bonhomme

Jean-Jacques Berthelon

Martine Daoust

Herv&eacute; Dumas

Fran&ccedil;ois Collonges

Nitromethyl ketone compounds having aldose reduction inhibiting properties and methods for their use

A pharmaceutical composition for the treatment of alcohol and drug dependence, comprising a therapeutically effective amount of a combination of: (i) an opioid antagonist; and (ii) a NMDA receptor complex modulator. A pharmaceutical kit is also provided, comprising these two substances. The opioid antagonist can, for example, be naltrexone and the NMDA receptor complex modulator can be a spermidine site modulator such as acamprosate.

Combination for the treatment of alcohol and drug dependence containing an opioid antagonist and a NMDA receptor complex modulator

The invention concerns novel compound of general formula (1) in which: P, T , T , X and n are as defined in claim 1, their tautomeric forms, and their additive salts with pharmaceutically acceptable bases. The invention also concerns methods for preparing these compounds and their applications as medicines. These compounds inhibit the aldose reductase enzyme and can be used in the treatment or prevention of peripheral and autonomous neurological diabetic complications, renal and ocular disorders such as cataract and retinopathy.

Nitromethylthiobenzene derivatives as inhibitors of aldose reductase

Aminoalkanesulphonic acid derivatives, their preparation and their use as medicaments

The present invention relates to the compounds of formula: ##STR1## in which R.sub.1, R.sub.2, R.sub.3, E, A, X, Z, p and n are as defined herein. These compounds are aldose reductase inhibitors.

Nitromethyl ketones, process for preparing them and compositions

The subject of the invention is compounds of general formula: ##STR1## in which: X represents O or CHR,

Benzocycloheptenes

Benzoxepines

3,4-dihydro-4-oxo-3-(2-propenyl)-1-phthalazineacetic acids and

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Villeurbanne, France

Philippe Durbin