Sanofi

Other

Sanofi-aventis

Akzo Nobel N.v.

Sanofi-synthelabo

Azko Nobel

Philippe Duchaussoy

Maurice Petitou

Jean Marc Herbert

Pierre Savi

Constant Van Boeckel

Pierre Alexandre Driguez

Jean-Marc Herbert

Pierre Fons

Cornelia Dreef-Tromp

Jean Pascal Herault

Johannes Basten

Peter Grootenhuis

Gilbert Lassalle

Constant Adriaan Anton Van Boeckel

Corentin Herbert

Johannes Egbertus Maria Basten

Cornelia Maria Dreef-Tromp

Alexandre Froidbise

Guy Jaurand

The invention relates to FGF receptor-activating N-sulfate oligosaccharides having Formula (I), wherein R, R, R, and Rare &#x2014;OSOor hydroxyl groups, Ris an &#x2014;O-alkyl group or a monosaccharide having Formula (II), Ris a disaccharide having Formula (III), Ris a disaccharide having Formula (IV), Ris a hydroxyl group or a disaccharide having Formula (VI), and Ris a hydroxyl or &#x2014;O-alkyl group or a disaccharide having Formula (VII), where R&#x2014; is an &#x2014;O-alkyl group. The invention further relates to the preparation of said oligosaccharides and to the therapeutic use thereof. 

FGF receptor-activating N-sulfate oligosaccharides, preparation thereof, and therapeutic use thereof

The invention relates to FGF receptor-activating N-acyl octasaccharides having Formula (I), wherein: Ris an O-alkyl group optionally replaced by one or more aryl or cycloalkyl groups, Ris an OSOor hydroxyl group, Ris an alkyl, cycloalkyl, or alkyl-cycloalkyl group, Ris a disaccharide having Formula (II), Ris a disaccharide having Formula (III), and Ris a disaccharide having Formula (IV), where R, R, and Rare OSOor hydroxyl groups. The invention further relates to the preparation of said octasaccharides and to the therapeutic use thereof. 

FGF receptor-activating N-acyl octasaccharides, preparation thereof, and therapeutic use thereof

The invention concerns novel biotinylated hexadecasaccharides of general formula (I) wherein: Biot is a biotin derivative; R, Rand R, represent independently of one another a C-Calkoxy or and &#x2014;OSO; Rrepresents a C-Calkoxy or an &#x2014;OSO, or Rconstitutes a &#x2014;O&#x2014;CH&#x2014; bridge; Pe represents a saccharide concatenation; as well as their pharmaceutically acceptable salts, and their use as medicines. 

Biotinylated hexadecasaccharides, preparation and use thereof

The present invention relates to novel synthetic polysaccharides with antithrombotic activity exhibiting at least one covalent bond with biotin or a biotin derivative and to a process employing avidin or streptavidin which makes it possible to neutralize these polysaccharides.

Polysaccharides with antithrombotic activity comprising at least one covalent bond with biotin or a biotin derivative

Synthetic polysaccharides are disclosed containing 8-24 monosaccharide units made up of a concatenation of disaccharides consisting of a uronic acid and a hexose, wherein the hydroxyl groups of the polysaccharides are etherified with a Calkyl group or esterified in the form of a sulpho group, each disaccharide being at least monoetherified; and salts thereof, are disclosed.

Synthetic polysaccharides, process for their preparation and pharmaceutical compositions containing them

Polysaccharides with antithrombotic activity comprising at least a covalent bond with biotin or a biotin derivative

A synthetic polysaccharide including an antithrombin III binding domain consisting of a concatenation of five monosaccharides supporting a total of two carboxylic acid functions and at least four sulpho groups, said domain being directly bound at the non-reducing end by a thrombin binding domain including a concatenation of 10-25 monosaccharide units selected from hexoses, pentoses or deoxy sugars of which all the hydroxyl groups are etherified by a C alkyl group or esterified in the form of sulpho groups, as well as salts and particularly pharmaceutically acceptable salts thereof, are disclosed.

Synthetic polysaccharides, preparation method therefor and pharmaceutical compositions containing same

Novel synthetic polysaccharides for use in the treatment of pathologies associated with a coagulation dysfunction.

Synthetic polysaccharides, their method of production and pharmaceutical compositions containing same

The invention relates to a carbohydrate derivative having formula I

Carbohydrate derivatives

Growing community of inventors

Toulouse, France

Philippe Duchaussoy