Fournier Laboratories Ireland Limited

Synkem

Philippe Dellis

Jean-Pierre Genet

Sébastien Duprat De Paule

Virginie Vidal

Kamel Nasar

Nicolas Champion

A process for preparing a quaternary ammonium salt of a fibric acid, represented by the following reaction scheme: is carried out in a single operation starting from a phenol of formula (I), an &#x3b1;-halogenated ester of formula (II) and a quaternary ammonium hydroxide of formula (III). This process makes it possible economically to prepare a choline salt of fenofibric acid in high purity that can be used directly as the active substance in a pharmaceutical composition intended for human consumption.

Process for preparing quaternary acid and ammonium salts

The invention relates to novel diphosphines, in optically pure or racemic form, of formula (I):in which: The invention further relates to the use of a compound of formula (I) as a ligand for the preparation of a metal complex useful as a chiral catalyst in asymmetric catalysis, and to the chiral metal catalysts comprising at least one ligand of formula (I).

Diphosphines, their complexes with transisition metals and their use in asymmetric synthesis

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Dijon, France

Philippe Dellis