Sanofi-aventis

Sanofi

Philippe Burnier

Frederic Puech

Adrien Tak Li

Jacques Froissant

Frank Marguet

Yulin Chiang

Christian Hoornaert

Ahmed Abouabdellah

Zhongli Gao

Antonio Almario Garcia

Benoit Marabout

Jean Jeunesse

Roy J Vaz

Pascal George

Frédéric Puech

Sylvain Cote Des Combes

Alain Gueiffier

Qiuxia Zhao

Matthieu Barrague

Benoît Marabout

Christophe Pacaud

Cécile Enguehard

Frederic Peuch

Cecile Enguehard-Gueiffier

Mathieu Barrague

Sylvain Cote-Des Combes

Adrien-Tak Li

Larry Davis

Jean-François Gilbert

The invention relates to the 6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine derivatives corresponding to general formula (I): Wherein R, R, R, A, L and B are as defined herein. Also disclosed are the preparative methods and therapeutic use thereof.

6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]-pyridazine and derivatives thereof preparation and therapeutic application thereof

The invention relates to the 6-cycloamino-3-(pyridin-4-yl)imidazo[I,2-b]pyridazine derivatives corresponding to general formula (I): Wherein R, R, R, R, A, L and B are as defined herein. Also disclosed are the preparative methods and therapeutic use thereof.

6-cycloamino-3-(pyrid-4-yl)imidazo[1,2-b]pyridazine derivatives, preparation thereof and therapeutic use thereof

6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine and derivatives and pharmaceutical compositions comprising the same

Therapeutic uses of a compound corresponding to the general formula (I): in which A=N or CR; R=H, F, OH, CN, CF, C-alkyl, C-alkoxy; n=2 or 3 and m=2 when A=N; n=1, 2 or 3 and m=1 or 2 when A=CR; B=covalent bond or C-alkylene; R=optionally substituted heteroaryl; R=CHRCONHR; R=H or C-alkyl; R=H, C-alkyl, C-cycloalkyl, C-cycloalkyl-C-C-alkylene;in the form of a base, an acid-addition salt, a hydrate or a solvate.

Therapeutic uses of derivatives of piperidinyl- and piperazinyl-alkyl carbamates

A subject-matter of the invention is the compounds of general formula (I) in which X represents a hydrogen or halogen atom;Rrepresents a hydrogen atom or a (C-C)alkyl group; Rand Reach represent, independently of one another, a hydrogen atom or a (C-C)alkyl group or else Rand Rform, with the nitrogen atom which carries them, a pyrrolidinyl, piperidinyl, morpholinyl or 4-alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, 1-oxidopyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl or pyridazinyl type, it being possible for the heteroaromatic group to carry one or more halogen atoms and/or one or more (C-C) alkyl or (C-C) alkoxy groups; in the form of bases, of addition salts with acids, of solvates or of hydrates, the pharmaceutical compositions comprising them, processes for their preparation and synthetic intermediates.

3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-B]indole-1-carboxamide derivatives, their preparation and therapeutic use

A subject-matter of the invention is the compounds of general formula (I) in which X represents a hydrogen or halogen atom; Rrepresents a hydrogen atom or a (C-C)alkyl group; Rand Reach represent, independently of one another, a hydrogen atom or a (C-C)alkyl group or else Rand Rform, with the nitrogen atom which carries them, a pyrrolidinyl, piperidinyl, morpholinyl or 4-alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, 1-oxidopyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl or pyridazinyl type, it being possible for the heteroaromatic group to carry one or more halogen atoms and/or one or more (C-C)alkyl or (C-C)alkoxy groups; in the form of bases, of addition salts with acids, of solvates or of hydrates, the pharmaceutical compositions comprising them, processes for their preparation and synthetic intermediates.

[object Object]

Compound corresponding to the general formula (I): in which A=N or CR; R=H, F, OH, CN, CF, C-alkyl, C-alkoxy; n=2 or 3 and m=2 when A=N; n=1, 2 or 3 and m=1 or 2 when A=CR; B=covalent bond or C-alkylene; R=optionally substituted heteroaryl; R=CHRCONHR; R=H or C-alkyl; R=H, C-alkyl, C-cycloalkyl, C-cycloalkyl-C&#x2013;C-alkylene; in the form of a base, an acid-addition salt, a hydrate or a solvate. Therapeutic uses thereof.

Derivatives of piperidinyl-and piperazinyl-alkyl carbamates, preparation methods thereof and application of same in therapeutics

The invention concerns compounds of general formula (I), wherein: X represents a hydrogen or halogen atom; Rrepresents a hydrogen atom or a (C&#x2013;C)alkyl group; Rand R, represent each, independently of each other, a hydrogen atom or a (C&#x2013;C)alkyl group, or Rand Rform, with the atom which bears them, a pyrrolidinyl, piperidinyl, morpholinyl or 4-alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, 1-oxidopyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl, pyridazinyl type, the heteroaromatic group may represent one or several halogen atoms and/or one or several (C&#x2013;C)alkyl, (C&#x2013;C)alkoxyl groups; in the form of bases, addition salts to acids, solvates or hydrates. The invention also concerns pharmaceutical compositions containing same, methods for preparing same and synthesis intermediates 

3-heteroaryl-3, 5-dihydro-4-oxo-4H-pyridazino[4, 5-b]indole-1-carboxamide derivatives their preparations and therapeutic use

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Maisons-Laffitte, France

Philippe Burnier