Sanofi-aventis

Sanofi-synthelabo

Synthelabo

Philippe Bovy

Sandor Batori

Tibor Szabo

Zoltan Kapui

Peter Aranyi

Katalin Urban-Szabo

Roberto Cecchi

Tiziano Croci

Christophe Philippo

Imre Bata

Edit Susan

Marton Varga

Eva Boronkay

Lajos T Nagy

Laszlo Balazs

Gilles Courtemanche

Karoly Kanai

Olivier Venier

Alain Jean Braun

G&eacute;rard Defosse

Endre Mikus

Maria Balogh

Olivier Crespin

Claudie Namane

Stefano Romagnano

Judit Bence

Patrick Mougenot

Eykmar Fett

Ambrogio Oliva

Nunzia Viviani

Zsuzsanna Tomoskozi

Laura Barzaghi

Michel Aletru

Marie Claire Orts

Stephen Eric O'Connor

Anne Marie Galzin

The present invention relates to new, potent DPP-IV enzyme inhibitors of the general formula (I), which contain fluorine atoms.

Fluoropyrrolidines having dipeptidyl peptidase enzyme inhibitory activity

The present invention relates to the orexin receptor antagonists compounds of the general formula (I) as well as to their isomers, salts and solvates, to the pharmaceutical compositions containing them and to the therapeutic application thereof.

Pyrazole derivatives and use thereof as orexin receptor antagonists

The present invention relates to the novel compounds of the general formula (I) possessing dipeptidyl peptidase IV enzyme inhibitory activity, pharmaceutical compositions thereof, methods of using said compounds, processes for their preparation and intermediates of the general formulae (II), (IV), (V), (VII), (VIII) and (IX).

Compounds useful for DPP-IV enzyme inhibition

The invention relates to the compounds of general formula (I) where Rrepresents H, a (C1-C4)alkyl, &#x2014;CO(C1-C4)alkyl, (C1-C4)alkylphenyl or &#x2014;CO-phenyl group, said phenyl being optionally substituted, Rrepresents H, a halogen atom, an &#x2014;S(O)R, &#x2014;NHSOR, &#x2014;NHSO-phenyl or &#x2014;NHSO&#x2014;(C1-C4)alkylphenyl group where z is equal to 0, 1 or 2 and where Rrepresents a (C1-C4)alkyl group, said phenyl being optionally substituted; where n is equal to 0, 1 or 2, Rand Rrepresent H, a (C1-C4)alkyl, hydroxyl, cyano, phenyl, benzyl, piperidyl, &#x2014;CONH, &#x2014;CO-phenyl, &#x2014;COOR, &#x2014;CH(phenyl) (OH) and &#x2014;C(phenyl)(OH) group, or Rand Rform together an optionally substituted 6-membered aromatic ring, Rrepresents H, a (C1-C4)alkyl, phenyl or benzyl group, and B represents a 5- or 6-membered nitrogen-containing heterocycle or homocycle optionally fused with a phenyl Group or optionally substituted; their addition salts; their method of preparation and their therapeutic application.

Oxophenyl-cyclohexyl-propanolamine derivatives, production and use thereof in therapeutics

The invention relates to compounds of general formula (I): 

Phenylcyclohexylpropanolamine derivatives, preparation and therapeutic application thereof

The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an &#x2014;S(O)(C-C)alkyl group, an &#x2014;NHSO(C-C)alkyl group, an &#x2014;SONH(C-C)alkyl group, an &#x2014;NHSOphenyl-(C-C)alkyl group or an &#x2014;NHSOphenyl group, said phenyl possibly being substituted with a halogen atom, with a (C-C)alkyl group or with a (C-C)alkoxy group; Rrepresents a hydrogen atom or a (C-C)alkyl group, a &#x2014;CO(C-C)alkyl group, a phenyl-(C-C)alkyl group or a &#x2014;COphenyl group, said phenyl also possibly being substituted with a halogen atom or with a (C-C)alkoxy group; Ris a hydrogen atom or an &#x2014;SO(C-C)alkyl group, an &#x2014;SOphenyl-(C-C)alkyl group or an &#x2014;SOphenyl group; X completes a ring of 5 to 8 atoms, said ring being saturated or unsaturated, possibly being substituted with one or two (C-C)alkyl groups and bearing one or two carbonyl groups; n, m and z are, independently, 0, 1 or 2; Rrepresents a hydrogen or halogen atom, a (C-C)alkyl group, a (C-C)alkoxy group, a &#x2014;COO(C-C)alkyl group, a &#x2014;CO(C-C)alkyl group, an &#x2014;NHSO(C-C)alkyl group, an &#x2014;NHSOphenyl-(C-C)alkyl groups, &#x2014;NO, &#x2014;CN, &#x2014;CONRR, &#x2014;COOH, or a 4,5-dihydro-1,3-oxazol-2-yl or 4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl group; Rand Rrepresent, independently, a hydrogen atom, a phenyl, a (C-C)alkyl group or a phenyl-(C-C)alkyl group or Rand Rwith the nitrogen atom to which they are attached, may form a ring of 5 to 7 atoms in total; and to the salts or solvates thereof, to the pharmaceutical compositions containing them, to a process for the preparation thereof and to intermediates in this process.

Cyclohexyl(alkyl)propanolamines, preparation method and pharmaceutical compositions containing same

Compounds

The invention relates to phenoxypropanolamines, to pharmaceutical compositions containing them, to processes for preparing them, and to the method of use thereof in the treatment of diseases that are improved by beta-3 agonist action.

Propanolaminotetralines, preparation thereof and compositions containing same

The invention concerns compounds of formula (I) wherein: A represents either a hydrogen atom or a hydroxyl group; B represents a pyrrolidin-2-yl (D) or 2-piperidyl (E), B capable of being substituted by one or two R groups; R represents a hydrogen atom, a C -C alkyl, a C -C alkenyl, a C -C perfluoroalkyl or a C -C fluoroalkyl group; R , R or R , independently of one another, represent a hydrogen atom, a C -C alkyl, group or a C -C alkenyl group, or R and R can together form a C -C alkylene chain, or a C -C alkenylene chain; R represents a C -C alkyl group, and R represents a hydrogen atom, a C -C alkyl group, a C -C alkenyl group, C -C cycloalkyl, C -C cycloalkenyl or a benzyl. Said compounds have therapeutic applications

8-(heterocyclylmethyl)quinoline derivatives for treating urinary incontinence

The invention relates to 1-aminoethylquinoline derivatives, to pharmaceutical compositions containing them, to therapeutic methods of using them and to processes for preparing them.

1-aminoethylquinoline derivatives for treating urinary incontinence

Imidazole derivatives, preparation and therapeutic application thereof

2-aminoethyl-benzofuran derivatives, preparation thereof and

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Mareil Marly, France

Philippe Bovy