Amgen Inc.

Amgen Sf, LLC

Philippe Bergeron

Julio Cesar Medina

Xiaohui Du

Xiaoqi Chen

Jeffrey Thomas Mihalic

Jason A Duquette

Jeffrey Deignan

Darin J Gustin

Zice Fu

Michael G Johnson

An-Rong Li

Andrew P Marcus

Lawrence R McGee

Jiwen Liu

Christopher Neil Farthing

John Walter Liebeschuetz

Stephen Clinton Young

Stuart Donald Jones

Sarah Lively

Sharon McKendry

David Sheppard

George R Tonn

Sarah E Lively

Stuart D Jones

Sharon Mckendry

Compounds are provided having the formula: wherein variables R, R, R, R, R, A, A, L, Q, X and subscript n as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases

Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PPAR&#x3b3; or PPAR&#x3b4;. In particular, the compounds of the invention modulate the function of PPAR&#x3b3; or PPAR&#x3b4;. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis.

Bisaryl-sulfonamides

Provided herein are compounds of the formula where A, A, A, A, L, Q, R, R, R, R, R, R, R, X, Y, Y, Yand Z are as described herein, and compositions thereof that are useful in the treatment of inflammatory and immune conditions and diseases. In particular, the invention provides aryl nitrile compounds which modulate the expression and/or function of a chemokine receptor.

Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders

Bisaryl-sulfonamide compounds having the formula wherein Ar, R, R, L, B, W, X, Y, and Z, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PPAR&#x3b3; or PPAR&#x3b4;. In particular, the compounds of the invention modulate the function of PPAR&#x3b3; or PPAR&#x3b4;. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis.

Compounds are provided having the formula: wherein variables A, A, A, A, R, R, R, R, Q and L are as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

[object Object]

Compounds are provided having the formula: wherein variables R, R, R, R, R, Q, L and subscript n are as described herein. The subject compounds are useful for treatment of infammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

Imidazolo-related compounds, compositions and methods for their use

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San Mateo, CA, United States of America

Philippe Bergeron