Genentech, Inc.

Xenon Pharmaceuticals Inc.

Rqx Pharmaceuticals, Inc.

Philippe Bergeron

Christoph Martin Dehnhardt

Brian Salvatore Safina

Sultan Chowdhury

Thilo Focken

Michael Edward Grimwood

Michael Scott Wilson

Abid Hasan

Shaoyi Sun

Qi Jia

Alla Yurevna Zenova

Ivan William Hemeon

Jean-Christophe Andrez

Paul Robert Bichler

Wei Gong

Kwong Wah Lai

Steven McKerrall

Daniel P Sutherlin

Michael F T Koehler

Cuong Q Ly

Ramsay Beveridge

Joseph P Lyssikatos

Tao Wang

Anthony A Estrada

Jacob Bradley Schwarz

Zhonghua Pei

Daniel Fred Ortwine

Frederick Cohen

Birong Zhang

James John Crawford

Claudio F Sturino

Prasuna Paraselli

Robert Higuchi

Kristen Nicole Burford

Peter Andrew Smith

Zhiguo Liu

Tucker Curran Roberts

Jean-Philippe Leclerc

Huiyong Hu

Liang Zhao

Alexandre Lemire

Xianrui Zhao

Kevin Hon Luen Lau

Teresa Phuongtram Nguyen

Robert I Higuchi

The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the variables Y-Y, X, Z, Z, Z, R-R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. The compounds have sodium channel blocking activity that are useful for treating sodium channel-mediated diseases, in particular for treating pain.

Pyridine-sulfonamide derivatives as sodium channel inhibitors

The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables R, R, subscript n, subscript q, ring A, X, L, subscript m, X, R, R, R, R, R, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Therapeutic compounds and methods of use thereof

The invention provides a compound of formula: or a salt thereof, wherein the variables R, n, ring A, ring B, R, R, R, R, R, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

The invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein the variables X, Y&#x2014;Y, R, R, R, R, and Het have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Macrocyclic broad spectrum antibiotics

The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables R, R, subscript n, subscript q, ring A, X, L, subscript m, X, R, R, R, R, R, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

Disclosed are compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR). 

Pyrimidine compounds, compositions and methods of use

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South San Francisco, CA, United States of America

Philippe Bergeron