Universitë De Bordeaux

Institut National De La Sante Et De La Recherche Medicale

Université´ D'aix-Marseille

Centre National De La Recherche Scientifique

Institut Jean Paoli & Irène Calmettes

Université De Bourgogne

Centre Regional De Lutte Contre Le Cancer

Centre National De La Recherche Scientifique-Cnrs

Institut National De La Sante Et De La Recherche Medicale (Inserm)

Centre Hospitalier Universitaire De Bordeaux

Philippe Barthelemy

Khalid Oumzil

Palma Rocchi

Julie Acunzo

Michel Camplo

Michael Ramin

Olivier Chassande

Laurent Latxague

Camille Ehret

Ananda Appavoo

Bruno Chauffert

Salim Khiati

Arnaud Gissot

Alain Thiery

Nathalie Campins

Amit Patwa

Florence Bouyer

Sylvie Crauste-manciet

Marc Sicard

Brune Vialet

The invention relates to bola-amphiphilic compounds and their uses for biomedical application. The invention particularly relates to the use of bola-amphiphilic compounds for providing low molecular weight gels (LMWG), useful, in particular, as culture media for animal or human cells, or as biocompatible material for biomedical applications.

Bola-amphiphilic compounds and their uses for biomedical applications

The invention relates to new nucleoside-lipid compounds with pH-sensitive dialkylorthoester chains, to the process for their preparation and to their uses, in particular their use for transportation or vectorization of at least one therapeutic agent.

Nucleoside-lipid compounds with pH-sensitive dialkylorthoester chains and their use for transportation or vectorization of at least one therapeutic agent

The present invention relates to the use of a supramolecular system in order to remove particles from a liquid medium containing same. According to the invention, the supramolecular system includes at least one molecule having a low molecular weight and/or an organic compound from living organisms, preferably from jellyfish, said compound being selected from among collagen, a polysaccharide, a proteoglycan or a mixture of two of said organic compounds, and said molecule having a low molecular weight and formula (I) as defined herein. The invention also relates to a method for removing particles from a liquid medium containing same. The invention is particularly suitable for use in water decontamination and biotechnology.

Hydrogel-based decontamination of aqueous samples containing nanoparticles

The present invention concerns an oligonucleotide modified by substitution at the 3' or the 5&#x2032; end by a moiety comprising at least three saturated or unsaturated, linear or branched hydrocarbon chains comprising from 2 to 30 carbon atoms, and the use therefore as a medicament, in particular for use for treating cancer.

Hydrophobically modified antisense oligonucleotides comprising a triple alkyl chain

The present invention concerns an oligonucleotide modified by substitution at the 3' or the 5&#x2032; end by a moiety comprising at least one ketal functional group, wherein the ketal carbon of said ketal functional group bears two saturated or unsaturated, linear or branched, hydrocarbon chains comprising from 1 to 22 carbon atoms, and the use therefore as a medicament, in particular for use for treating cancer.

Hydrophobically modified antisense oligonucleotides comprising a ketal group

The invention relates to a method for preparing nanoparticles based on functional amphiphilic molecules or macromolecules, optionally in the presence of at least one colipide, enabling the encapsulation of therapeutic agents, especially anti-tumoral agents, and the use thereof for the transport and vectorization of therapeutic agents, especially anti-tumoral agents.

Method for preparing nanoparticles based on functional amphiphilic molecules or macromolecules, and the use thereof

The invention relates to novel functional amphiphilic molecule or macromolecule formulations with multiple compartments for transporting or targeting at least one therapeutic agent, in particular an antitumor agent, as well as to a method for preparing such formulations and to the use thereof.

Functional amphipilic molecule or macromolecule formulations with multiple compartments

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Merignac, France

Philippe Barthelemy