Janssen Vaccines & Prevention B.v.

Complix Nv

Philippe Alard

Stefan Loverix

Ronald Vogels

Katarina Radosevic

Jan Willem Meijberg

Antonietta Impagliazzo

Robert H E Friesen

Ignace Lasters

Johan Desmet

Robert Heinz Edward Friesen

Klaartje Somers

Sabrina Deroo

Jan Wilem Meijberg

Provided herein are polypeptides that are capable of crossing the cellular membrane and entering into the intracellular environment, which polypeptides are suitable for use in prophylactic, therapeutic or diagnostic applications as well as in screening and detection. Nucleic acids encoding such polypeptides; methods for preparing such polypeptides, host cells expressing or capable of expressing such polypeptides, compositions, and in particular pharmaceutical compositions, that comprise such polypeptides, in particular for prophylactic, therapeutic or diagnostic purposes are also provided.

Polypeptides capable of cellular internalization

The present disclosure provides influenza hemagglutinin stem domain polypeptides comprising (a) an influenza hemagglutinin HA1 domain that comprises an HA1 N-terminal stem segment, covalently linked by a linking sequence of 0-50 amino acid residues to an HA1 C-terminal stem segment, and (b) an influenza hemagglutinin HA2 domain, wherein on or more amino acids in the HA2 domain have been mutated. Also provided are nucleic acids encoding the polypeptides, compositions comprising the polypeptides and/or nucleic acid molecules, as well as methods of their use, in particular in the detection, prevention and/or treatment of influenza.

Influenza virus vaccines and uses thereof

Growing community of inventors

Merelbeke, Belgium

Philippe Alard