Nanostring Technologies, Inc.

Institute for Systems Biology

Zymogenetics, Inc.

Philippa Jane Webster

Timothy Dahl

Krassen M Dimitrov

Gary K Geiss

Sean M Ferree

Richard Kemble Boykin

Eric H Davidson

Lucas M Dennis

Edward C Thayer

Tim Dahl

Jeannette Nussbaum

Lucas Michael Dennis

The present invention relates to compositions and methods for detection and quantification of individual target molecules in biomolecular samples. In particular, the invention relates to improved, stable nanoreporter probes that are capable of binding to and identifying target molecules based on the probes' uniquely detectable signal. Methods for identifying target-specific sequences for inclusion in the probes are also provided, as are methods of making and using such probes. Polynucleotide sequences of certain nanoreporter components are also provided. The probes can be used in diagnostic, prognostic, quality control and screening applications.

Stable nanoreporters

The present invention relates to compositions and methods for detection and quantification of individual target molecules in biomolecular samples. In particular, the invention relates to coded, labeled probes that are capable of binding to and identifying target molecules based on the probes' label codes. Methods of making and using such probes are also provided. The probes can be used in diagnostic, prognostic, quality control and screening applications.

Nanoreporters and methods of manufacturing and use thereof

The application describes methods for diagnosing subjects with leukemia by detecting fusion genes associated with the onset of leukemia.

Compositions and methods for diagnosing cancer

The invention provides compositions and methods for the detection of small RNA molecules in a multiplexed reaction. The assays and kits described herein are applicable for the identification, diagnosing, and monitoring of disorders including, but not limited to cancer, developmental and degenerative disease, neurological disorders, and stem cell disorders.

Compositions and methods for the detection of small RNAs

The present invention relates to polynucleotide and polypeptide molecules, and variants thereof, for Zzp1, a novel Zona Pellucida protein. The polypeptides, and polynucleotides encoding them, are fertility modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the Zzp1 polypeptides.

Human secreted protein, Zzp1

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Seattle, WA, United States of America

Philippa Jane Webster