Lonza Inc.

Lonza Solutions Ag

Arxada Ag

Philipp Studer

Oleg Werbitzky

Christian Schnider

Michael Bersier

Andreas Klein

Stefan Tille

Thomas Gruetzner

Anna-Christina Hormes

Claudio Arnold

Simon Kessler

The invention discloses a method for the preparation of 2-chloro acetoacetic acid amide or ester by a reaction of acetoacetic acid amide or ester with trichloroisocyanuric acid in the presence of amylene and in the solvent acetone.

Method for preparation of 2-chloroacetoacetic acid amide and ester

The invention relates to a method for the preparation of bis(fluorosulfonyl)-imide and its derivatives at elevated temperature.

Method for preparation of bis(fluorosulfonyl)-imide

A process for the production of 2-chloro-5-chloromethylpyridine of the formula: ##STR1## starting from 6-hydroxynicotinic acid of the formula: ##STR2## In this way 6-hydroxynicotinic acid is reacted with an acid chloride to 6-hydroxynicotinoyl chloride of the formula: ##STR3## The latter is then catalytically hydrogenated with hydrogen to 6-hydroxy-5-hydroxymethylpyridine of the formula: ##STR4## The latter is then catalytically hydrogenated with hydrogen to 2-hydroxy-5-hydroxymethylpyridine of the formula: ##STR5## which is then chlorinated to the end product according to formula I.

Process for the production of 2-chloro-5-chloromethyl-pyridine

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Visp, Switzerland

Philipp Studer