Tecan Trading Ag

Uster Technologies Ag

Tegan Trading Ag

Philipp Ott

Adrian Sager

Patrick D Kinney

Sujata Iyer

Thomas Geiges

Lars Kamm

Markus Schöni

Paul Zbinden

Matthias Dzung

Martin Kuster

Dominic Erb

Nicolas Cors

Reto Gehrig

Rolf Joss

Michael Keller

Sara Ferdi

Theo Meier

Philipp Riedel

Thomas Struchen

Carsten Hase

Volfgang Vilaj

Markus Schoeni

Raffael Bueler

Luca Frei

Pascal Dieterich

Daniel Kessler

Yves Wurmitzer

Andreas Schenk

David Papencordt

Hagen Reinhardt

Remo Keller

Pascal Dietrich

Raffael BÜELER

Markus SCHÖNI

Lars Johan BRANDÉN

Simon Strassen

A method for aspirating a first liquid medium of two liquid media of different density from a sample container comprises: lowering a pipette of the laboratory automation device into the sample container until a pipette tip of the pipette has passed a lowering distance from the surface of the first liquid medium in the sample container, wherein the lowering distance is chosen, such that the pipette tip passes at least an aspiration volume in the sample container; aspirating liquid from the sample container during the lowering of the pipette by generating an underpressure in the pipette, wherein the first liquid medium is aspirated, and after the interface and the pipette tip pass each other, the second liquid medium of the two liquid media is aspirated; measuring a pressure in the pipette during the lowering of the pipette and detecting a position of the interface, when a slope of the pressure changes; when the lowering distance has been passed and no interface is detected, aspirating the aspiration volume from the first liquid medium and dispensing the aspiration volume of the first liquid medium into a further sample container.

Iterative liquid aspiration

Some embodiments are directed to a method for tracking lysis progress in an automated lysing device. For example, the lysing device may be configured to execute multiple iterations of lysing at a defined location on the tissue section and imaging the defined location on the tissue section using a camera. From the images a lysing parameter may be determined to improve lysing.

Tracking of lysing at a location on a tissue section

Some embodiments are directed to a method for detaching tissue from a tissue section on a tissue slide. The method may include applying a 3D printed mask on top of the tissue section, the mask comprising barriers that define a cavity surrounding an area of interest on the tissue section, the cavity being open at a side facing the area of interest on the tissue section, dispensing a detaching liquid to the cavity, and allowing the detaching liquid to detach tissue at the area of interest, and aspirating the detaching liquid with the detached tissue from the cavity, and forwarding the liquid for further processing.

3D-printed mask for lysing at a location on a tissue section

A pipette tip extension having a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end is disclosed. The exterior wall has an outer side and an inner side and encloses an inner cavity which is delimited by the inner side of the exterior wall. The exterior wall forms at the proximal end a reception aperture. The pipette tip extension further has one or more distance elements arranged at the inner side of the exterior wall and protruding into the inner cavity.

Pipette tip extension, pipette tip, assembly of pipette tip and pipette tip extension, and method of use

A pipette tip extension attachable to a pipette tip is disclosed. The pipette tip extension has a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end. The exterior wall has an outer side and an inner side and forms at the proximal end a reception aperture for inserting a pipette tip. The pipette tip extension also has a bottom at the distal end, an inner cavity enclosed by the inner side of the exterior wall and the bottom, and one or more distance elements arranged at the inner side of the exterior wall and protruding into the inner cavity.

Tip cup

A method of treating an isolated area of a sample with a liquid is disclosed. The method has the steps of generating an isolated area of a sample by a first fluid reservoir where the first fluid reservoir enclosing a distal end of a second fluid reservoir and the isolated area of the sample being sealed towards the remaining area of the sample, bringing the isolated area of the sample into fluid connection with the second fluid reservoir, dispensing a fluid from the second fluid reservoir into the first fluid reservoir thereby generating a fluid flow on the sample at the isolated area in a first direction, and aspirating the fluid from the first fluid reservoir into the second fluid reservoir thereby generating a fluid flow on the sample at the isolated area in a second direction.

Method of treating a sample

A displacement device for displacing a displacement volume is disclosed. The device has a first fluid space and a second fluid space. A first piston is arranged in a movable manner within the first fluid space. The first fluid space is connectable to a pipetting device. The first piston is actuatable by an actuation volume of air or of liquid provided by the pipetting device. A second piston is arranged in a movable manner within the second fluid space. The second piston is constructed to displace a displacement volume of a fluid located within the second fluid space when the second piston is actuated. The second piston is actuated in dependence on the first piston that is actuated by the actuation volume. The actuation volume is different from the displacement volume, and a pipetting system has a displacement device and a method of displacing a displacement volume.

Displacement device and method for displacing fluid volumes

A pipette tip extension attachable to a pipette tip having a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end is disclosed. The exterior wall has an outer side and an inner side and forms at the proximal end a reception aperture for inserting a pipette tip, and at the distal end a dispense aperture. The pipette tip extension further has an inner cavity, a distance element connected to the inner side of the exterior wall, and a constriction element.

Pipette tip extension for treating a sample with a liquid attachable to a pipette tip

A pipette tip extension attachable to a pipette tip is disclosed. The pipette tip extension has a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end. The exterior wall has an outer side and an inner side and forms at the proximal end a reception aperture for inserting a pipette tip. The pipette tip extension further has a bottom at the distal end, an inner cavity enclosed by the inner side of the exterior wall and the bottom, one or more distance elements arranged at the inner side of the exterior wall and protruding into the inner cavity, and a coating for interacting with a fluid present in a fluid uptake area.

Coated tip cup

A combinable cavity tray for liquid handling is provided. The combinable cavity tray has at least one cavity for receiving a fluid and at least one passage for leading through a cavity of a second combinable cavity tray and/or for connecting to a pipetting apparatus. The at least one cavity of the combinable cavity tray is formed integrally. An assembly of combinable cavity trays having at least two combinable cavity trays, a method of manufacturing a combinable cavity tray and the use of a combinable cavity tray or of an assembly of combinable cavity trays for liquid handling are provided.

Combinable cavity tray, assembly of combinable cavity trays, method of manufacturing and use of a combinable cavity tray

A method for controlling a magnetic valve and particularly a method for dispensing and/or aspirating a volume of liquid as well as a corresponding dispenser/pipetting apparatus is disclosed. The method for controlling a magnetic valve has measuring a capacitance at the magnetic valve and determining a position of a plunger based on the measured capacitance. The method for dispensing or aspirating a volume of liquid has controlling a flow of a system fluid by a magnetic valve located between a pressure source and a dispenser/pipetting tip, dispensing or aspirating a volume of liquid through an exterior opening of the tip dependent on the flow of the system fluid, wherein controlling the flow and determining a flow time in dependence of the volume of liquid to be dispensed or aspirated, and controlling the magnetic valve is held open for the duration of the flow time.

Method for controlling a magnetic valve and method for dispensing or aspirating a volume of liquid as well as corresponding dispenser/pipetting apparatus

A pipetting apparatus having a pipette tube with a first end provided with an opening for aspirating and/or dispensing of a sample fluid and a second end operationally connected to a pressure generating means. The pipetting apparatus has at least one measuring unit adapted to determine at least one measurement value of the sample fluid based on the aspirating and/or dispensing of the sample fluid and to provide a sample fluid measurement signal representative thereof to an output of the measuring unit. The pipetting apparatus also has a control circuit operationally coupled to the output of the measuring unit and the input of the pressure generating means, the control circuit is configured to control said pressure generating device based on the sample fluid measurement signal.

Pipetting apparatus, a liquid handling system and a method of controlling pipetting

A device for controlling an optical recognition unit with the help of a capacitive filling level measurement in liquid containers having a sensor with a measuring electrode, a conductive base plate suitable for arranging at least one liquid container or a carrier unit having at least one receptacle for receiving a liquid container, a sensor electronics unit that is connected to the measuring electrode and the base plate adapted to determine a capacitance between the measuring electrode and base plate, an evaluation unit, and a control unit for controlling the optical recognition unit, is disclosed.

Device and method for controlling an optical recognition unit with the help of a capacitive filling level measurement in liquid containers

A pipetting apparatus and method capable of detecting a liquid within an intermediate section of a pipette tube of the pipetting apparatus. The intermediate section is located between an upper section of the pipette tube at which a first electrode is arranged and a lower section at which a second electrode is arranged. The first and second electrodes form a measurement capacitor and are operationally connected to an impedance measurement unit, which is adapted to detect whether liquid, such as a portion of a sample liquid or system liquid, is present within the intermediate section based on the measured impedance or change of impedance, e.g. an increase of the capacitance and/or a decrease of the resistance, of the measurement capacitor caused by a presence of the liquid within the intermediate section.

Pipetting apparatus with a pipette tube and method for detecting a liquid within an intermediate section of a pipette tube

Devices and corresponding methods for capacitive foam detection in liquid containers are disclosed. The device has a sensor with a measurement electrode having a plurality of sub-electrodes, a bottom plate that is used as a counter electrode for arranging a liquid container, a sensor electronic unit that is connected to the measurement electrode and the bottom plate and is adapted to determine an impedance, in particular a capacitance, between the measurement electrode and the bottom plate, and an evaluation unit, the measurement electrode being arranged substantially perpendicularly to the bottom plate.

Growing community of inventors

Steg im Tosstal, Switzerland

Philipp Ott