University Health Network

Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum

Merck Patent Gmbh

Philipp Lang

Tak Wah Mak

Karl Lang

Pamela S Ohashi

Michael W Tusche

Dirk Brenner

Gloria Lin

Norbert Beier

Rolf Gericke

Thomas Fuchss

Florian Lang

Siegfried Waldegger

Angelika Lampert

Hannsjoerg Seybert

Nikola Jeck

The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.

Methods and compositions for modulating toso activity

Methods and compositions for modulating Toso activity

The present invention relates to a method for diagnosing hypertension, and/or allergy, and/or hair loss, and/or liabilty for infection, of a human being, or a predisposition therefor; to a nucleic acid molecule coding for a human ClCKb protein comprising a genetic alteration at amino acid positioncompared to the wild type, as well as for corresponding segments thereof; to a nucleic acid molecule which binds to the before-mentioned nucleic acid molecule under stringent conditions, as well as to a nucleic acid molecule which binds to that nucleic acid molecule; to a (poly)peptide encoded by the afore-mentioned nucleic acid molecules; to a method for identifying substances modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid positioncompared to the wild type; to a substance for modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid positioncompared to the wild type; to methods for preparing a pharmaceutical composition for treatment of hypertension, and/or allergy, and/or hair loss, and/or liability for infection; to pharmaceutical compositions; and to a method for treating a human being affected by hypertension, and/or allergy and/or hair loss, and/or liability for infection.

CICKb mutation as a diagnostic and therapeutical target

Growing community of inventors

Duesseldorf, Germany

Philipp Lang