Novartis Ag

Philipp Krastel

Erwin Paul Schreiner

Brigitta-Maria Liechty

Esther Schmitt

Matthew J LaMarche

Josef Gottfried Meingassner

Roger A Fujimoto

Liying Jocelyn Tan

Bin Zou

Seh Yong Leong

Shi Hua Ang

Wei Lin Josephine Wong

Bryan K S Yeung

Jennifer A Leeds

Hans-Ulrich Naegeli

Bryan Ks Yeung

The present application relates to cyclic depsipeptides, or derivatives thereof, having the structure of formula (I), and uses thereof, e.g. as inhibitors of kallikrein 7 and human neutrophil elastase.

Cyclic depsipeptides

The present application describes a method of treating a bacterial infection comprising administering to a subject in need thereof a pharmaceutically acceptable amount of a defined macrocycle compound.

Macrocycles and their uses

The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases.

The present application relates to cyclic depsipeptides of Formula I: or derivatives thereof, wherein X, A, A, A, A, A, Aand Aare defined herein. The cyclic depsipeptides of Formula I are inhibitors of kallikrein 7 and thus can be employed for the treatment of kallikrein-7 dependent diseases.

Use of cyclic depsipeptides to inhibit kallikrein 7

The invention relates to organic compounds which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused byand parasites of thegenus such as, for example.. The invention also relates to pharmaceutical compositions containing the compounds, as well as processes for their preparation.

Organic compounds

The invention relates to organic compounds which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused byand parasites of thegenus such as, for example,. The invention also relates to pharmaceutical compositions containing the compounds, as well as processes for their preparation.

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Grenzach-Wyhlen, Germany

Philipp Krastel