Biontech Se

Johannes Gutenberg-Universität Mainz

Philipp Heller

Heinrich Haas

Anne Schlegel

Benjamin Weber

Matthias Barz

Sara Nogueira

The present disclosure relates to RNA particles for delivery of RNA to target tissues after administration, in particular after parenteral administration such as intravenous, intramuscular, subcutaneous or intratumoral administration, and compositions comprising such RNA particles. The RNA particles in one embodiment comprise single-stranded RNA such as mRNA which encodes a peptide or protein of interest, such as a pharmaceutically active peptide or protein. The RNA is taken up by cells of a target tissue and the RNA is translated into the encoded peptide or protein, which may exhibit its physiological activity.

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Mainz, Germany

Philipp Heller