The University of Texas System

Albert Einstein College of Medicine

Philipp Erich Scherer

Zhiqiang An

Ningyan Zhang

Jiyoung Park

Shangang Zhao

Hui Deng

Puneeth Iyengar

Dawei Bu

Aspects of the present invention relate to methods and reagents for increasing chemosensitivity to platinum-based chemotherapy. In one aspect, a method of increasing chemosensitivity to platinum-based chemotherapy is provided, comprising administering to a patient in need thereof an effective amount of an endotrophin-neutralizing agent. The agent can be a monoclonal antibody, or fragment thereof, capable of binding to the C5 domain of the alphas chain of collagen VI. In some embodiments, the method can further include administering an effective amount of thiazolidinedione to said patient.

Monoclonal antibodies against endotrophin and the use thereof

Antibody antigen binding domains which specifically binds human leptin comprises Vor VCDR1, CDR2 and CDR3 sequences of an hLept antibody. The antibody antigen binding domains and antibodies thereof are useful to treat obesity and diabetes.

Leptin antibodies and method of reducing leptin

Leptin antibodies

Obesity and/or diabetes are treated by partially inhibiting circulating leptin in a person in need thereof.

Weight loss regimen

Aspects of the present invention relate to methods and reagents for increasing chemosensitivity to platinum-based chemotherapy. In one aspect, a method of increasing chemosensitivity to platinum-based chemotherapy is provided, comprising administering to a patient in need thereof an effective amount of an endotrophin-neutralizing agent. The agent can be a monoclonal antibody, or fragment thereof, capable of binding to the C5 domain of the alpha3 chain of collagen VI. In some embodiments, the method can further include administering an effective amount of thiazolidinedione to said patient.

Endotrophin neutralization and use thereof

Methods of determining whether a cancer is progressing by measuring surface-bound collagen VI&#x3b1;3 are provided. Also provided are methods of identifying hyperplasia in a tissue by measuring surface-bound collagen VI&#x3b1;3. Additionally, methods of identifying carcinoma in a tissue by measuring surface-bound collagen VI&#x3b1;3 are provided. Further provided are methods of imaging carcinoma in a tissue by staining the tissue with a specific binding partner to collagen VI&#x3b1;3. Methods of treating a cancer by preventing binding of collagen VI&#x3b1;3 onto cells of the cancer are additionally provided.

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Southlake, TX, United States of America

Philipp Erich Scherer