Comera Life Sciences, Inc.

Reform Biologics, LLC

Soane Energy, LLC

Self-suspending Proppant LLC

Reform Biologies, LLC

Philip Wuthrich

Robert P Mahoney

David S Soane

Rosa Casado Portilla

Mark Moody

Daniel G Greene

Gangadhar Jogikalmath

Marie Kyoko Herring

Kevin P Kincaid

Neil L Schauer

Ian Slattery

Timothy Tran

Subhashchandra Naik

Yuhong Zeng

The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid protein formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions. The inventive methods can also yield a higher stability of a liquid protein formulation.

Excipient compounds for biopolymer formulations

Viscosity-reducing compounds for protein formulations

The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions.

Viscosity-reducing excipient compounds for protein formulations

Disclosed herein are methods for improving a parameter of a protein-related process comprising providing a viscosity-reducing excipient compound selected from the group consisting of hindered amines, anionic aromatics, functionalized amino acids, oligopeptides, short-chain organic acids, and low molecular weight aliphatic polyacids, and adding a viscosity-reducing amount of the viscosity-reducing excipient compound to a carrier solution for the protein-related process, wherein the carrier solution contains a protein of interest, and carrier solutions comprising a liquid medium in which is dissolved a protein of interest, and a viscosity-reducing excipient, wherein the viscosity of the carrier solution has a lower viscosity that that of a control solution that is substantially similar to the carrier solution except for the presence of the viscosity-reducing excipient.

Excipient compounds for protein processing

The invention encompasses therapeutic formulations comprising a protein active ingredient and a stabilizing excipient, methods of improving stability in a therapeutic formulation comprising a protein active ingredient by adding a stability-improving amount of a stabilizing excipient to the therapeutic formulation, and methods of reducing adverse infusion-related effects in a patient, comprising administering to a patient in need thereof a therapeutic formulation comprising a protein active ingredient and a stabilizing excipient.

Stabilizing excipients for therapeutic protein formulations

The invention provides for modified proppants, comprising a proppant particle and a hydrogel coating, wherein the hydrogel coating localizes on the surface of the proppant particle to produce the modified proppant, methods of manufacturing such proppants and methods of use.

Self-suspending proppants for hydraulic fracturing

The invention provides formulations for facilitating the removal of oil from a surface using a chisel composition, wherein the chisel composition includes a polymer having one or more binding points with a high affinity for the surface, and one or more hydrophilic segments that form a hydrophilic coating on the surface, rendering the surface water-wet and thereby facilitating the removal of oil from the surface. The invention also provides for methods of use of such formulations.

Formulations and methods for removing hydrocarbons from surfaces

Self-suspending proppants for hydraulic fracturing comprising a coating of hydrogel-forming polymer

Growing community of inventors

Belmont, MA, United States of America

Philip Wuthrich