Xencor, Inc.

Philip W Hammond

John R Desjarlais

Gregory Alan Lazar

Sher Bahadur Karki

Seung Yup Chu

Bao-lu Chen

Lori Kunkel

David F Carmichael

Bao-Lu Chen

An antibody that targets CD30, wherein the antibody comprises at least one modification relative to a parent antibody and the antibody binds with altered affinity to an Fc&#x3b3;R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the anti-CD30 antibody.

Optimized anti-CD30 antibodies

An antibody that targets CD30, wherein the antibody comprises at least one modification relative to a parent antibody and the antibody binds with altered affinity to an FcgR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the anti-CD30 antibody.

The present invention relates to novel methods for generating variant proteins with increased host string content, and proteins that are engineered using these methods.

Methods of generating variant proteins with increased host string content

The present invention relates to novel methods for generating variant proteins with increased host string content by comparing a parent protein sequence with two or more natural protein sequences from a host species, analyzing one or more amino acid strings of the parent protein sequence with a structurally corresponding amino acid string of each of said natural protein sequences, substituting one or more amino acid strings of the parent protein sequence with a structurally corresponding amino acid string of one of the two or more natural protein sequences on an amino acid string by amino acid string basis so that the variant protein has increased host string content, and, synthesizing and screening the variant protein.

Growing community of inventors

Sierra Madre, CA, United States of America

Philip W Hammond