Gen-probe, Inc.

Gen-probe Products Company

Philip W Hammond

Patricia C Gordon

Nick Mark Carter

Steven T Brentano

Diane L McAllister

James John Hogan

Daniel L Kacian

Nanibhushan Dattagupta

Sherrol Hoffa McDonough

Thomas B Ryder

Anthony Endozo

Anthony A Endozo

Lyle J Arnold

Curt L Milliman

Alexander A Waldrop, Iii

Hybridization assay detection probes targeted to HPV Type 16 nucleic acid sequences which are particularly useful to aid in detecting HPV type 16 are described. The oligonucleotides can aid in detecting HPV Type 16 by acting singly or as part of a detection probe mixture. Compositions, reaction mixtures and methods of use are provided.

Hybridization assay detection probes for detecting human papilloma virus in a sample

Oligonucleotides targeted to HPV Type 16 and/or Type 18 nucleic acid sequences which are particularly useful to aid in detecting HPV type 16 and or 18 are described. The oligonucleotides can aid in detecting HPV Type 16 and/or Type 18 in different ways such as by acting as hybridization assay probes, helper probes, and/or amplification primers.

Oligonucleotides for detecting human papilloma virus in a test sample

The present invention describes oligonucleotides targeted to HPV Type 16 and/or Type 18 nucleic acid sequences which are particularly useful to aid in detecting HPV type 16 and or 18. The oligonucleotides can aid in detecting HPV Type 16 and/or Type 18 in different ways such as by acting as hybridization assay probes, helper probes, and/or amplification primers.

Oligonucleotides for use in determining the presence of human papilloma virus in a test sample

A method, composition and kit for synthesizing multiple copies of a target nucleic acid sequence autocatalytically under conditions of substantially constant temperature, ionic strength, and pH are provided in which multiple RNA copies of the target sequence autocatalytically generate additional copies using a mixture of blocked and unblocked primers and/or promoter-primers to initiate DNA and RNA synthesis, preferably with reduced non-specific product formation. The invention is useful for generating copies of a nucleic acid target sequence for purposes that include assays to quantitate specific nucleic acid sequences in clinical, environmental, forensic and similar samples, cloning and generating probes.

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Hybridization assay probes are described which are able to distinguish Mycobacterium avium complex organisms from related organisms.

Nucleic acid probes to Mycobacterium avium complex

Hybridization assay probes are described which are able to distinguish Ureaplasma and known strains or serotypes of the species Ureaplasma urealyticum found in humans from other related organisms.

Nucleic acid probes to ureaplasma

The present invention describes oligonucleotides targeted to Mycoplasma pneumoniae nucleic acid sequences which are particularly useful to aid in detecting Mycoplasma pneumoniae. The oligonucleotides can aid in detecting Mycoplasma pneumoniae in different ways such as by acting as hybridization assay probes, helper probes, and/or amplification primers.

Nucleic acid hybridization assay probes, helper probes and amplification

Detecting Mycobacterium tuberculosis by nucleic acid sequence

Hybridization assay probes specific for members of the Mycobacterium tuberculosis Complex and no other Mycobacterium species.

Nucleic acid probes to mycobacterium tuberculosis

Methods of amplifying nucleic acids using promoter-containing primer

Hybridization assay probes specific for Chlamydia pneumoniae and no other Chlamydia species.

Nucleic acid probes to Chlamydia pneumoniae

This invention discloses hybridization assay probes for Mycobacterium kansasii comprised of an oligonucleotide of about 18 nucleotides. These probes hybridize to a variable region of the 23S rRNA gene of Mycobacterium kansasii. The oligonucleotide probes are complementary to the rRNA variable region of the rRNA gene. Such probe specificity offers a rapid, non-subjective method of identification and quantitation of a bacterial colony for the presence of selected rRNA sequences capable of distinguishing all strains of Mycobacterium kansasii.

23S rRNA nucleic acid probes to mycobacterium kansasii

The present invention describes oligonucleotides targeted to Mycoplasma pneumoniae nucleic acid sequences which are particularly useful to aid in detecting Mycoplasma pneumoniae. The oligonucleotides can aid in detecting Mycopplasma pneumoniae in different ways such as by acting as hybridization assay probes, helper probes, and/or amplification primers.

Growing community of inventors

San Diego, CA, United States of America

Philip W Hammond