The University of Texas System

University of Illinois

Philip Shaul

Joachim Herz

Xunde Xian

Chieko Mineo

Laurent Calvier

Yinyuan Ding

Linzhang Huang

John A Katzenellenbogen

Sung Hoon Kim

Benita Katzenellenbogen

Zeynep Madak-Erdogan

The present invention provides methods and compositions for treating atherosclerosis in a subject comprising the use of therapeutic compounds to reduce Reelin in the circulation of the subject, thereby reducing the adhesion of leukocytes to the vascular wall. The invention also provides methods and compositions for reducing leukocyte adhesion to the vascular wall in a subject.

Reelin antibodies for treatment of atherosclerosis

Provided are compounds of formulae provided herein. The compounds may include pathway-preferential estrogens (PaPEs) derivatives with tissue-selective activities. Also provided are pharmaceutical compositions comprising the compounds, as well as methods of treating a disease or condition including administering the compounds. The disease or condition may include postmenopausal symptoms, cardiovascular disease, stroke, vascular disease, bone disease, metabolic disease, arthritis, osteoporosis, obesity, vasomotor/hot flush, cognitive decline, cancer including breast cancer.

Compounds which activate estrogen receptors and compositions and methods of using the same

Methods and compositions for treatment of atherosclerosis

Growing community of inventors

Austin, TX, United States of America

Philip Shaul