Leland Stanford Junior University

The United States Government As Represented by the Department of Veterans Affairs

Va Palo Alto Health Care System

Philip S Tsao

John P Cooke

Christopher Heeschen

James Jang

Anjali Pathak

Frances Lauri Johnson

Joshua M Spin

Uwe Raaz

Isabel N Schellinger

Michael P Snyder

Jingjing Li

Cuiping Pan

Sai Zhang

Processes to identify a subset of trait-related genes and classify individuals are described. Generally, systems generate classification models which are used to identify the subset of trait-related genes and classify individuals. The classification models are also used in various applications, including developing research tools, performing diagnostics, and treating individuals.

Processes for genetic and clinical data evaluation and classification of complex human traits

Methods, compositions, and devices for treating a vascular aneurysm, including an abdominal aortic aneurysm, are disclosed. In particular, the various embodiments relate to a method of treating an abdominal aortic aneurysm by increasing the mechanical stiffness of an aortic segment adjacent to the abdominal aortic aneurysm in a subject. The mechanical stiffness of the adjacent aortic segment may be increased, for example, by applying a surgical adhesive or intravascular stent. Such treatment reduces stress on the aortic wall and limits further growth of the abdominal aortic aneurysm.

Methods, devices, and compositions for treating vascular aneurysms

Methods, devices, and compositions for treating abdominal aortic aneurysms

The present invention features methods for recruitment of bone marrow-derived stem cells (e.g., endothelial cell precursors, hematopoietic stem cells) by administration of nicotine or other nicotine receptor agonist. The methods of the invention can be used in, for example, treatment of conditions amenable to treatment by recruitment of bone marrow-derived stem cells (e.g., neutropenia).

Nicotine receptor agonists in stem cell and progenitor cell recruitment

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Los Altos, CA, United States of America

Philip S Tsao