Therox, Inc.

Wayne State University

Angiosonics Inc.

Philip S Levin

Paul J Zalesky

J Richard Spears

Vincent Divino

Loi Nguyen

Jon Saltonstall

Warren Taylor

Uri Rosenschein

J Christopher Flaherty

Jay Caplan

An ultrasound transmission device for utilizing ultrasound energy ultrasound to treat intravascular conditions, such as stenotic and occluded regions of blood vessels, is provided. The ultrasonic transmission device includes a transmission member connectable to the ultrasound energy source on a one end and a tip on the other end. The tip includes a distal section, a proximal section and an intermediate section. The proximal section has a first diameter larger than the transmission member diameter. The intermediate section includes a decreasing step portion, a narrowed portion, and an increasing step portion.

Ultrasound transmission apparatus having a tip

The present invention includes a fluid delivery device capable of delivering perfusion or other fluids to a vascular site. Preferred embodiments permit delivery of large quantities of fluid without causing recoil of the device, and without causing trauma to the vascular site.

Angioscopy apparatus and methods

The present invention includes a guidewire device capable of delivering perfusion fluids to a vascular site while at the same time exhibiting handling characteristics associated with existing non-perfusion guidewires. Preferred embodiments include a perfusion guidewire which closely matches the dimensions and physical characteristics of standard guidewires. Preferred embodiments also permit high pressure perfusion of supersaturated solutions, and include a liquid flow path which will not promote bubble generation or growth, or destabilize a supersaturated solution.

High pressure perfusion device

An ultrasonic treatment system and method for utilizing ultrasound to treat intravascular conditions, such as stenotic and occluded regions of blood vessels, are provided. The ultrasonic treatment system includes an ultrasonic probe, having a proximal and distal end. A guide catheter and guidewire may also be provided and the probe can be slidably disposed within the guide catheter's inner lumen. The probe can include a horn at the proximal end, a transmission member with a proximal and a distal end connected to the horn at the transmission member proximal end, and a distal tip connected at the transmission member's distal end. The transmission member may include one or more transmission wires, having proximal and distal ends, connected serially or in parallel.

Ultrasound transmission apparatus and method of using same

High pressure transluminal fluid delivery device

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Thompson, CT, United States of America

Philip S Levin