University System of Maryland

The University of Texas System

Wichita State University

Philip R DeShong

L Scott Rodkey

Stefanie N Vogel

Douglas Stephen English

Daniel C Stein

Lenea Stocker

Katharina Richard

Srinivasa R Raghavan

Anand Prakash

Gregory F Payne

Matthew Dowling

Michael R Zachariah

Marc-Raleigh Brescia

Michael C Patterson

Amy S Manoso

Eric D Soli

Molly E Mowery

Peter DeMuth

Charles Luckett

Neeraja Dashaputre

Vishal Javvaji

Christopher J Handy

The disclosure relates to compositions, pharmaceutical compositions, vaccines, and methods of making and using the same. The compositions of the disclosure are useful to stimulate an antigen-specific immune response and, in some embodiments, a protective immune response in an animal after challenge to pathogens. The compositions of the disclosure are also useful for treatment and prevention of disease in a subject such as cancer.

Compositions and vaccines comprising vesicles and methods of using the same

A method for synthesizing a mesoporous silica nanoparticle, a mesoporous silica nanoparticle, and applications thereof are provided. The method includes fractionating a mesoporous silica nanoparticle suspension to produce size-fractionated mesoporous silica nanoparticle. The method further includes etching the size-fractionated mesoporous silica nanoparticle to produce synthesized mesoporous silica nanoparticle having a hollow, porous morphology configured to receive one of a therapeutic agent and an imaging material. The etching includes differential etching of silica from areas of low polymeric density within the mesoporous silica nanoparticle and re-depositing of the silica in areas of higher polymeric density existing near the surface of the mesoporous silica nanoparticle. A target material is loaded into the synthesized mesoporous silica nanoparticle and a controlled released of the target material is provided by decreasing the physiological pH of the surface of the mesoporous silica nanoparticle.

Method for forming mesoporous silica nanoparticles, mesoporous silica nanoparticles, and applications thereof

A biosensor comprising an electrically conductive substrate coated with a modified chitosan biopolymer that has been electrodeposited on the substrate, wherein said modified chitosan biopolymer comprises at least one vesicle binding molecule. The biosensor is manufactured by a method where a modified chitosan biopolymer is electrodeposited on a substrate. The method is also used to manufacture a modified chitosan biopolymer film by electrodeposition of the chitosan on the substrate and later removing the film from the substrate after electrodeposition. The resulting film can be used in bandages to treat various types of wounds. The biosensor can also be used to detect various analytes in samples.

Method and system for capture and use of intact vesicles on electrodeposited hydrophobically modified biopolymer films

Hypervalent silane and siloxane reagents (preformed or generated in situ) for transmetalation in palladium catalyzed reactions with derivatives of allylic alcohols, aryl halides, electron-withdrawing aryl bromides, and aryl triflates derived from phenols are disclosed. Also disclosed are methods of preparing glycosyl azides by reaction of an azide with a silyl ester in the presence of a phoshine.

Hypervalent silane and siloxane derivatives and the use thereof

New synthesis and analysis procedures for novel crosslinked polyamines and ampholytes. Polyamines are crosslinked with tartaric acid ester, malonic acid ester, or polycarboxylic acid esters of the citric acid cycle. The resulting crosslinked polyamine may further react with other compounds such as an .alpha.,.beta.-unsaturated or .alpha.-halo unsaturated carboxylic acids to prepare new ampholyte mixtures. The resulting novel ampholytes exhibit greater heterogeneity and complexity than presently prepared ampholytes, and can be used in analytical and preparative isoelectric focusing processes. Novel ampholyte analysis process entails analyzing chemical compounds, usually ampholytes, used in isoelectric focusing processes. The ampholyte is isoelectrically focused on an immobilized pH gradient, and then immersed in a picric acid solution to cause precipitation and visualization of amphoteric species. The isoelectrically focused and visualized ampholyte compounds may be photographed or analyzed densitometrically to compare it with other isoelectrically focused and visualized ampholytes to determine relative heterogeneity of the ampholytes over given pH ranges.

Synthesis of complex polyamines for ampholyte production

Growing community of inventors

Silver Spring, MD, United States of America

Philip R DeShong