Stryker Trauma Gmbh

Stryker European Holdings I LLC

Biomimetic Innovations Limited

Other

Sulzer Mixpac Ag

Gpbio Ltd.

Celgentek Limited

Philip Procter

Hartwig Steckel

Torben Christian Sörensen

Gerard Insley

Michael Pujari-palmer

Håkan Engqvist

Andreas Werner Speitling

Mirjam Lilja

Christian Schultz

Ulrike Lindequist

Joachim Schomburg

Frieder Schauer

Annett Mikolasch

Katrin Manda

Jan Henrik Sörensen

Andy Greter

Benjamin Nieber

Ken Welch

David Russell

Wolf-Dieter Jülich

Gerard Michael Insley

Kieran Murray

Wolf Dieter Jülich

Kevin David Madden

Jan Soerensen

Anders Jönsson

Jörg Arnoldi

Michael Pujari-Palmer

Carol O' Sullivan

Jan Henrik Soerensen

Torben SÖRENSEN

Anett Mikolasch

The present invention relates to an aqueous composition comprising an aqueous solution, α-TCP, a silicate compound and a phosphorylated amino acid. The composition has improved mechanical strength and is easily applied and may be used as a tissue adhesive, implant or a filler.

Composition of alpha-TCP, silicate and phosphorylated amino acid

The present invention relates to a soft tissue adhesive comprising an aqueous composition comprising α-TCP and a phosphorylated amino acid. The composition has improved mechanical strength and is easily applied to the tissue.

Soft tissue adhesive composition of α-TCP and phosphorylated amino acid

The present invention relates to a composition of a calcium phosphate such as tetracalcium phosphate or α-TCP and an additive compound selected from nucleic acid or nucleotides, phospho(enol)pyruvic acid and phosphocreatine. The composition may be used as a tissue adhesive.

Composition of a calcium phosphate and an additive compound containing a phosphate or phosphonate group

A method of manufacturing an implant for use in a surgical procedure, a corresponding implant and the use thereof during the incorporation of a substance is presented. Specifically anodized and blasted titanium implant substrates are provided with a hydroxyapatite (HA) coating for incorporating for example a therapeutic agent. In particular, an anodizing procedure by an electrolytic process in an alkaline liquid is carried out. Moreover, blasting of the anodized titanium implant substrate is carried out by the presented method. The HA coating can be in the range of 1 to 5 &#x3bc;m, particularly in the range of 1 to 3 &#x3bc;m. A local delivery of the active pharmaceutical ingredient is achieved by the implant of the present invention. Moreover, the implant allows for the removal of the implant without damaging surrounding tissue or a bone. Moreover, the HA coating is provided to the substrate such that enhanced fixation as measured by pull-out force is achieved whilst having a relatively low removal torque. The HA coating and drug incorporation may be carried out sequentially but also co-precipitation approach can be used.

Method of manufacturing an implant for use in a surgical procedure

A discharge device () comprising a housing (), a container insert () rotatably arranged therein and a piston. A lateral cutout () is formed in one housing wall (), and a lateral container opening () is formed in one container wall (). In order to prevent the compound from being compressed as the compound is discharged, the lateral container opening extends continuously as far as the distal container end () without a region of the container wall adjoining the lateral container opening in the distal direction along the longitudinal axis. In order to make it easier to put in the compound, the wall thickness of the housing wall decreases continuously toward the lateral cutout (). In order to prevent clogging of the piston, the cross section of the container insert widens continuously in the distal direction.

Discharge device for bone replacement materials

A method for co-precipitating a therapeutic agent into a hydroxyapatite coated surface includes the steps of providing a surface and applying a hydroxyapatite seed layer on the surface. The hydroxyapatite seed layered surface is contacted with a solution including the therapeutic agent and a co-precipitated therapeutic agent, hydroxyapatite layer is formed on the coated surface to uniformly distribute the therapeutic agent in the layer. Further, an implant having sustained therapeutic agent delivery includes a base and an hydroxyapatite seed layer disposed on a surface of the base. A co-precipitated hydroxyapatite coating is disposed on the seed layer. The coating includes a therapeutic agent, wherein the therapeutic agent is provided in a solution of therapeutic agent.

Co-precipitation of a therapeutic agent into hydroxyapatite coatings

A method for loading a hydroxyapatite coated implant with a therapeutic agent including the steps of providing an implant and applying a hydroxyapatite coating on a surface of the implant. The hydroxyapatite coated implant is contacted with a solution including the therapeutic agent. The hydroxyapatite coated implant and solution is heated to temperature of about 60&#xb0; C. to about 100&#xb0; C. Pressure is applied to the hydroxyapatite coated implant and solution from about 2 bar to about 10 bar, to load the hydroxyapatite coated implant with the therapeutic agent. An implant made according to the method has sustained therapeutic agent delivery and includes a base and a biomimetic hydroxyapatite coating disposed on a surface thereof.

Method for drug loading hydroxyapatite coated implant surfaces

A method for delivering a bisphosphonate and/or strontium ranelate below the surface of a bone using a mechanical force. The method includes the steps of combining a bisphosphonate and/or strontium ranelate with a carrier to form a delivery composition and delivering an effective amount of the delivery composition below the surface of the bone with a mechanical force. Also provided is a method for strengthening a portion of a bone. This method includes the step of delivering an effective amount of a bisphosphonate and/or strontium ranelate below the surface of a portion of a bone with a mechanical force.

Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone

An implantation device for fixating a bone has a main body. The main body has a peripheral region and comprises a polymeric material. The peripheral region comprises the polymeric material and a plasticizer. In particular, the peripheral region may be adapted to be fixed to a bone. A method for producing the implantation device includes the steps of forming an implantation device using polymer material, and dipping at least a portion of the implantation device into a plasticizer in such a way that a peripheral region of the implantation device is plasticized.

Implantation device, method for producing and for applying the same

The invention relates to adhesives for medical applications and methods of their preparation and use.

Adhesive for medical applications and means for haemostasis

The invention relates to a kit comprising the following individual components: (a) polymers comprising at least one free amino group, (b) bridge molecules selected from the group consisting of monocyclic ortho-dihydroxyaromates, mono-cyclic para-dihydroxyaromates, bicyclic monohydrxyaromates, polycyclic monohydroxyaromates, bicyclic dihydroxyaromates, polycyclic dihydroxyaromates, bicyclic trihydroxyaromates, polycyclic trihydroxyaromates, and mixtures thereof, and (c) polyphenoloxidases, in particular, lignolytic polyphenoloxidases, whereby the individual components b) and c) are not in contact.

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Divonne Les Bains, France

Philip Procter