Forsyth Dental Infirmary for Children

Other

The Forsyth Institute

Novalar Pharmaceuticals, Inc.

Philip P Stashenko

Yi-Ping Li

Anne L Wucherpfennig

Mario Abdennour

Michele Scrime

Jack Gilad

Max Goodson

Toshihisa Kawai

Kazuhisa Ohara

Richard Battaglino

Yoshiaka Hosokawa

Ulrike Späte

Yoshitaka Hosokawa

Yoshimura Okamatsu

Hajime Sasaki

The present invention relates to oral antibacterial compositions comprising trihydroxybenzoate derivatives, e.g., useful for the treatment of gum diseases (e.g., gingivitis or periodontitis) and to methods of using such compositions.

Antibacterial compositions

The present invention features methods of treating a bone resorption disease or a bone generating disease, methods for prognosing and/or diagnosing a bone resorption disease or a bone generating disease, methods for identifying a compound that modulates bone resorption disease development or bone generating disease development, methods for determining the efficacy of a bone resorption disease therapy or a bone generating disease therapy, and oligonucleotide microarrays containing probes for genes involved in osteoclast development.

Method of inhibiting an activity of a gene product in a bone cell encoded by a nucleotide sequence comprising SEQ ID NO: 50

Endodontic fibers including a biocompatible polymer vehicle permeable to medicaments, or combinations of medicaments, and method of using such endodontic fibers are described. Such fibers can be used, for example, in a method for the local delivery and sustained release of medicaments to intracanal treatment sites.

Characterization of an antibiotic impregnated delivery system as an intracanal medicament in endodontic therapy

Endodontic fibers comprising a biocompatible polymer vehicle permeable to medicaments, or combinations of medicaments are described. Such fibers can be used, for example, in a method for the local delivery and sustained release of medicaments to periodontal or intracanal treatment sites. Endodontic fibers described include modified periodontal fibers and intracanal fibers.

Methods and compounds for remodeling bone and treating osteopenic conditions are described. Methods and compounds for increasing bone mineral density by decreasing serotonin levels in osteoblasts are also described.

Methods for increasing bone density

Novel gene encoding a human 116-kDa osteoclast proton pump subunit and the protein encoded thereby. Methods of treatment of bone mass disorders utilizing said gene, and antibodies that bind to the protein encoded by said gene.

Osteoclast proton pump subunit

Characterization of an antibiotic impregnated delivery system as an intracanal medicament in endodontic therapy and method

The present invention relates to purified osteoclast-specific or -related DNA sequences and a method for identifying such sequences. DNA constructs capable of replicating osteoclast-specific or -related DNA and DNA constructs capable of directing expression in a host cell of osteoclast-specific or -related DNA are also described.

Human osteoclast-specific and -related DNA sequences

The present invention relates to purified DNA sequences encoding all or a portion of an osteoclast-specific or -related gene products and a method for identifying such sequences. The invention also relates to antibodies directed against an osteoclast-specific or -related gene product. Also claimed are DNA constructs capable of replicating DNA encoding all or a portion of an osteoclast-specific or -related gene product, and DNA constructs capable of directing expression in a host cell of an osteoclast-specific or -related gene product.

Human ostoclast-specific and -related genes

The present invention relates to a method of identifying DNA encoding an osteoclast-specific or -related gene product. The method comprises hybridizing DNA with a stromal cell+, osteoclast+probe, or with cDNA or mRNA from an osteoclastoma, and with a stromal cell+, osteoclast-probe, or with cDNA or mRNA from stromal cells; and identifying DNA which hybridizes to the stromal cell+, osteoclast+probe, or to cDNA or mRNA from osteoclastoma, but not to the stromal cell+, osteoclast-probe, or to cDNA or mRNA from stromal cells.

Methods of identifying human osteoclast-specific and related genes

Human osteoclast-specific and -related genes

The present invention comprises a method for the determination of periodontal disease active sites within the human oral cavity by a measurement of the level of interleukin 1 beta (IL-1b) in oral tissues and gingival crevicular fluid at a particular site.

Growing community of inventors

Medfield, MA, United States of America

Philip P Stashenko