Georgia Tech Research Corporation

Emory University

Queen's University at Kingston

Kingston Health Sciences Centre

Philip M Zakas

Christopher B Doering

Eric Gaucher

H Trent Spencer

Harold Trent Spencer

Caelan Radford

David Lillicrap

A recombinant von Willebrand Factor (VWF) protein comprising one or more mutations and uses thereof are described. A recombinant protein complex comprising a von Willebrand factor sequence and one artificial Factor VIII sequence is described. A recombinant protein complex comprising a Factor VIII sequence and one artificial von Willebrand sequence is described. A recombinant protein complex is described that includes one artificial von Willebrand factor sequence and one artificial Factor VIII sequence. Also described are nucleic acid sequences and a vector encoding a VWF sequence and a pharmaceutical composition for inducing blood clotting that includes a VWF protein.

Von Willebrand factor proteins for treating bleeding disorders

This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more protein domains comprise amino acid sequences that are derived from ancestrally reconstructed amino acid sequences. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising the proteins or vectors and related methods of inducing blood clotting.

Factor VIII proteins having ancestral sequences, expression vectors, and uses related thereto

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Atlanta, GA, United States of America

Philip M Zakas