Bristol-myers Squibb Compnay

Philip M Wallace

Jeffrey A Ledbetter

Peter S Linsley

William Brady

Nitin Krishnaji Damle

Thomas J Brown

Robert Peach

Jurgen Bajorath

Robert J Peach

The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.

Soluble CTLA4 mutant molecules

The present invention provides soluble CTLA4 mutant molecules which bind CD80 and/or CD86 antigen.

Soluble CTLA4 mutant molecules and uses thereof

Oncostatin M is employed in methods to treat acute and chronic gastrointestinal inflammation, rheumatoid arthritis and multiple sclerosis.

Oncostatin M for treating inflammation

The present invention relates to methods of using oncostatin M (OM). In particular, it relates to the use of OM to stimulate interleukin 6 (IL-6) synthesis in target cells, especially human endothelial cells. The resultant IL-6, in turn, may perform a variety of functions such as cell growth regulation, leukocyte differentiation, and tumor inhibition. Furthermore, the present invention also relates to the use of OM to treat cytopenias, including anemia and thrombocytopoiesis, and to increase tolerance to irradiation and cytotoxic drugs. Therefore, the methods of the invention may have a wide range of applications, including, but not limited to, the inhibition of tumor growth, the treatment of cytopenias, and to increase the tolerance to radio- and chemotherapy. OM may be used in combination with various cytokines, including erythropoietin, colony-stimulating factors, interleukin-3 or thrombopoietin.

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Seattle, WA, United States of America

Philip M Wallace