Scienceplusplease, LLC

Scienceplusplease Llc, Dba Cerebroscope

Philip M Sauter

Nicolas Alexander Alba

Prahlad Menon Gopalakrishna

Stephen Carter Jones

Samuel J Hund

Alexander Kharlamov

Eric Singer

Nicolas A Alba

The present invention provides systems and methods for detection and diagnosis of concussion and/or acute neurologic injury comprising a portable headwear-based electrode array and computerized control system to automatically and accurately detect cortical spreading depression and acute neurological injury-based peri-infarct depolarization (CSD/PID). The portable headwear-based electrode system is applied to a patient or athlete, and is capable of performing an assessment automatically and with minimal user input. The user display indicates the presence of CSD/PID, gauges its severity and location, and stores the information for future use by medical professionals. The systems and methods of the invention use an instrumented DC-coupled electrode/amplifier array which performs real-time data analysis using unique algorithms to produce a voltage intensity-map revealing the temporally propagating wave depressed voltage across the scalp that originates from a CSD/PID on the brain surface.

Non-invasive systems and methods to detect cortical spreading depression for the detection and assessment of brain injury and concussion

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Pittsburgh, PA, United States of America

Philip M Sauter