Janssen Pharmaceutica Nv

Philip James Pye

Andras Horvath

Jinxiong Su

Yuanyuan Yuan

Bernardus Kaptein

Cheng Yi Chen

Simon Albert Wagschal

Shuo Wang

Laurent Lefort

Gerardus Karel Maria Verzijl

Disclosed is a process for the preparation of certain intermediates, e.g. process for preparing a compound of formula (I) or a pharmaceutically acceptable salt thereof, in an enantioenriched form, which intermediate and processes are useful in the preparation of a BTK inhibitor, such as ibrutinib.

Processes and intermediates for preparing a Btk inhibitor

Disclosed is a process for the preparation of certain intermediates, e.g. a process for preparing a compound of formula (I) wherein, R, Rand Xare as defined in the description, and which intermediate and processes are useful in the preparation of a BTK inhibitor, such as ibrutinib.

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Philip James Pye