University of California

State of Oregon

Philip J Proteau

William H Gerwick

Ferran Garcia-Pichel

Richard Castenholz

Robert S Jacobs

James Rossi

Krista J Grace

Dale G Nagle

Indole alkaloid compounds having the formula ##STR1## where R and R' are H, an alkyl group having up to 5 carbon atoms or --CO--(CH.sub.2).sub.n --CH.sub.3 where n=0 to 16. The indole alkaloid compounds and their reduction products are useful as both UV protective and anti-inflammatory agents.

Indole alkaloids useful as UV protective and anti-inflammatory agents

Anti-flammatory method using indole alkaloids

Isomers of a cytotoxic compound isolated and purified from a marine cyanobacterium Lyngbya majuscula are disclosed. The isomers termed Curacin A and Curacin B exhibits substantial biological activity against proliferating cells. The Curacin A and Curacin B isomers appear to be antimitotics. Methods for using the isomers are also disclosed.

Compound exhibiting antiproliferative activity against cells

Growing community of inventors

Murray, UT, United States of America

Philip J Proteau