Chiron Corporation

Lxr Biotechnology, Inc.

Tanox, Inc.

Novartis Vaccines & Diagnostics, Gmbh

University of Georgia Research Foundation Inc

Genetics Institute, Inc.

Kosan Biosciences Incorporated

New York University

Genentech, Inc.

The United States of America As Represented by the Department of Health

University of Hawai'i

Genetech, Inc.

The United States of America As Represented by the Secretary of Health

Baxter International Inc.

Baxter Healthcare Sa

Philip J Barr

Michael C Kiefer

Ian C Bathurst

L David Tomei

Helen L Gibson

John D Bradley

Dino Dina

Pablo D Valenzuela

Paul A Luciw

Carlos George-Nascimento

Martha Truett

Deborah Lynn Parkes

Kathelyn S Steimer

Ray Sanchez Pescador

Rob Hallewell

Patricia A Tekamp-Olson

Daniel V Santi

Gary W Ashley

George Kuo

Randal J Kaufman

James Travis

Anthony J Brake

Rainer Ziermann

Paul Andrew Fitzpatrick

Louise C Wasley

Nadine Pavloff

Philip A Pemberton

Polly A Wong

Michael C Keifer

Steven Rosenberg

Frank R Masiarz

Victor N Nussenzweig

David C Kaslow

Jan Stanislaw Potempa

Charles K Marlowe

Pablo D T Valenzuela

Jianping Sun

John P Shapiro

Guy T Mullenbach

Rae Lyn Burke

Robert A Hallewell

Mickey S Urdea

Jeffrey R Shuster

Sandra Chang

Matthew W Foehr

James P Merryweather

John G Goddard

Pablo Dt Valenzuela

Robert Neil Pike

George S N Hui

Timothy Kreiger

J Stanislaw Potempa

Ken Kabingue

Virginia Mosher

Louise Wasley

Randal J 111 Marlborough Street Kaufman

Harish Kumar

Manzer J Durrani

The present invention relates generally to production methods, enzymes and recombinant yeast strains for the biosynthesis of clinically important prenylated polyketides of the cannabinoid family. Using readily available starting materials, heterologous enzymes are used to direct cannabinoid biosynthesis in yeast.

Recombinant production systems for prenylated polyketides of the cannabinoid family

The invention relates to the production of aromatic molecules in prokaryotic and eukaryotic hosts such as, yeasts, filamentous fungi, algae, microalgae, other plant cells.

Recombinant prodcution systems for aromatic molecules

Recombinant production systems for aromatic molecules

The present invention encompasses methods and compositions for the treatment and prevention of chronic obstructive pulmonary disease (COPD) or emphysema, typically smoking-induced emphysema. More specifically, the present invention relates to the treatment and prevention of COPD or emphysema by inhalation of alpha one-antitrypsin (AAT).

Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor

Vectors, host cells, and methods are provided for the production of proteins in yeast. The vectors generally contain a selection gene, a yeast 2 micron sequence, and a polynucleotide encoding a polypeptide, where the polynucleotide is operably linked to promoter, and where the polynucleotide contains one or more yeast-preferred codons. Host cells are cultured under conditions where, after an initial batch phase, oxygen concentration is kept high and glucose feed is regulated so that the yeast cells stay in respiratory metabolism.

Method of protein production in yeast

The present invention provide polynucleotide sequences encoding a Bak Binding Protein (BBP) and fragments thereof that bind to Bak. The invention also provide recombinant host cells containing polynucleotides encoding BBP. The invention further provide antibodies that specifically bind to BBP. The invention further provide methods for detecting agents such as drugs that alter the binding of a BBP with a Bak protein. The invention further provide methods for detecting the presence of Bak polynucleotides and the encoding proteins in a biological sample, and further provide methods for modulating the levels of BBP in a cell. This invention additionally encompasses novel peptides, designated the 'BBP Binding Domains' and the respective nucleotides, designated 'bbpbd-1' and &#x201c;bbpbd-2&#x201d; which are involved in the interaction between Bak and BBP.

Bak binding protein, DNA encoding the protein, and methods of use thereof

The present invention provides a novel family of apoptosis-modulating proteins. Nucleotide and amino acid residue sequences and methods of use thereof are also provided.

Methods and compositions for detecting CDN apoptosis-modulating proteins

Fusion proteins of protease inhibitors are provided, in particular fusion proteins of alpha 1-antitrypsin (AAT) and a second protease inhibitor, such as secretory leukocyte protease inhibitor (SLPI) or tissue inhibitor of metalloproteases (TIMP). Polynucleotides encoding the fusion proteins, vectors comprising such polynucleotides, and host cells containing such vectors are also provided. Methods of making the fusion proteins of the invention are also provide, as well as methods of using the fusion proteins, for example to inhibit protease activity in a biological sample or in the treatment of an individual suffering from, or at risk for, a disease or disorder involving unwanted protease activity.

Multifunctional protease inhibitors and their use in treatment of disease

Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.

Purified pol DNA, a recombinant DNA construct for expression of HIV pol polypeptide sequences and a cell containing such construct

Method for expressing HIV polypeptides

Recombinant DNA construct for HIV envelope polypeptides and polypeptides produced thereby

Methods of protein production in yeast

Human immunodeficiency virus (HIV) nucleotide sequences

The present invention provides polynucleotide sequences (bbp) encoding a Bak Binding Protein (BBP) and fragments thereof that bind to Bak. The invention also provides a BBP which binds to Bak. The invention also provides recombinant host cells containing polynucleotides encoding BBP. The invention further provides antibodies that specifically bind to BBP. The invention further provides methods for detecting agents such as drugs that alter the binding of a BBP with a Bak protein. The invention further provides methods for detecting the presence of bbp or BBP in a biological sample, and further provides methods for modulating the levels of BBP in a cell. This invention additionally encompasses novel peptides, designated the 'BBP Binding Domains' and the respective nucleotides, designated 'bbpbd-1' and &#x201c;bbpbd-2&#x201d; which are involved in the interaction between Bak and BBP.

Growing community of inventors

Oakland, CA, United States of America

Philip J Barr