Janssen Pharmaceutica Nv

Spear Therapeutics Limited

Naeja Pharmaceuticals Inc.

Philip Huxley

Mark Stuart Chambers

Wolfgang Schmidt

Martin James Inglis Andrews

Kim Louise Hirst

Juha Andrew Clase

Paul John Edwards

Angus MacLeod

Gregory Bar

Veronique Birault

Clifford John Harris

Reginald Christophe Xavier Brys

Ronald G Micetich

Rajeshwar Singh

Mark Whittaker

Gerard Andrew Potter

Jadwiga Kaleta

Andhe V Narender Reddy

Kenneth James Beresford

Paul Edwards

A compound for use in the treatment of proliferative disorders, such as cancer, having the following formula: wherein:

Compounds

Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases

Novel imidazo[-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

This invention relates to substituted azetidin-2-ones and to pharmaceutical compositions containing such compounds. Their use in medicine as inhibitors of cysteine proteases, particularly the cathepsins is also described. The invention includes a compound of formula (I), Y represents &mdash;C(O)&mdash; or &mdash;S(O )&mdash;; R represents an allyl (ie CH &boxH;CHCH &mdash;) group or a radical. R represents &mdash;OCOR , &mdash;OR , &mdash;SR , &mdash;S(O)R , or &mdash;S(O) R ; R represents a radical. R represents &mdash;OR or R ; or a pharmaceutically acceptable salt, hydrate or solvate thereof.

Substituted azetidin-2-ones as cysteine protease inhibitors

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Freeland, United Kingdom

Philip Huxley